Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2036129..2036643 Replicon chromosome
Accession NZ_CP012120
Organism Staphylococcus aureus strain USA300_2014.C02

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ACO02_RS10500 Protein ID WP_000581792.1
Coordinates 2036434..2036643 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ACO02_RS10495 Protein ID WP_000138932.1
Coordinates 2036129..2036422 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACO02_RS10460 2031392..2032033 + 642 WP_000483153.1 thiamine phosphate synthase -
ACO02_RS10465 2032119..2032991 + 873 WP_000725802.1 membrane protein insertase YidC -
ACO02_RS10485 2033804..2034451 - 648 WP_001187629.1 HD domain-containing protein -
ACO02_RS10490 2034479..2035963 - 1485 WP_000571549.1 cardiolipin synthase -
ACO02_RS10495 2036129..2036422 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ACO02_RS10500 2036434..2036643 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ACO02_RS10505 2036771..2036908 + 138 WP_000828354.1 hypothetical protein -
ACO02_RS10510 2037172..2038374 - 1203 WP_001109939.1 rod shape-determining protein RodA -
ACO02_RS10515 2038692..2039762 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
ACO02_RS10520 2039777..2041135 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T55816 WP_000581792.1 NZ_CP012120:2036434-2036643 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T55816 NZ_CP012120:2036434-2036643 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT55816 WP_000138932.1 NZ_CP012120:2036129-2036422 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT55816 NZ_CP012120:2036129-2036422 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References