Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 482859..483336 Replicon chromosome
Accession NZ_CP012120
Organism Staphylococcus aureus strain USA300_2014.C02

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag ACO02_RS02505 Protein ID WP_000052078.1
Coordinates 483148..483336 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ACO02_RS02500 Protein ID WP_001059690.1
Coordinates 482859..483119 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACO02_RS02465 478252..478968 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
ACO02_RS02470 479116..479538 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
ACO02_RS02475 479937..480431 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
ACO02_RS02480 480586..481203 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
ACO02_RS02485 481276..481857 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
ACO02_RS02490 482082..482318 + 237 WP_000368687.1 hypothetical protein -
ACO02_RS02495 482315..482518 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ACO02_RS02500 482859..483119 + 261 WP_001059690.1 hypothetical protein Antitoxin
ACO02_RS02505 483148..483336 + 189 WP_000052078.1 hypothetical protein Toxin
ACO02_RS02510 483524..484093 + 570 WP_001106654.1 hypothetical protein -
ACO02_RS02515 484181..484465 + 285 WP_001004395.1 hypothetical protein -
ACO02_RS02520 484527..484745 + 219 WP_000005886.1 hypothetical protein -
ACO02_RS02525 485241..485441 - 201 WP_001059082.1 cold-shock protein -
ACO02_RS02530 485798..486484 - 687 WP_001548082.1 thermonuclease family protein -
ACO02_RS02535 486825..487296 - 472 Protein_482 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T55807 WP_000052078.1 NZ_CP012120:483148-483336 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T55807 NZ_CP012120:483148-483336 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT55807 WP_001059690.1 NZ_CP012120:482859-483119 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT55807 NZ_CP012120:482859-483119 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References