Detailed information of TA system TA055796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1340152..1340681
• Replicon: chromosome
• Accession: NZ_CP012119
• Organism: Staphylococcus aureus strain USA300_2014.C01

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: AC807_RS07470
• Protein ID: WP_000621175.1
• Coordinates: 1340152..1340514 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: AC807_RS07475
• Protein ID: WP_000948331.1
• Coordinates: 1340511..1340681 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC807_RS07445	1337131..1337901	-	771	WP_001041103.1	RNA polymerase sigma factor SigB	-
AC807_RS07450	1337876..1338355	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
AC807_RS07455	1338357..1338683	-	327	WP_001052491.1	anti-sigma factor antagonist	-
AC807_RS07460	1338802..1339803	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
AC807_RS07470	1340152..1340514	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
AC807_RS07475	1340511..1340681	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
AC807_RS07480	1340766..1341914	-	1149	WP_001281145.1	alanine racemase	-
AC807_RS07485	1341980..1342339	-	360	WP_000581200.1	holo-ACP synthase	-
AC807_RS07490	1342343..1342834	-	492	WP_001205910.1	PH domain-containing protein	-
AC807_RS07495	1342821..1344404	-	1584	WP_001294626.1	PH domain-containing protein	-
AC807_RS07500	1344397..1344875	-	479	Protein_1356	hypothetical protein	-
AC807_RS07505	1345083..1345643	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T55796 WP_000621175.1 NZ_CP012119:c1340514-1340152 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T55796 NZ_CP012119:c1340514-1340152 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT55796 WP_000948331.1 NZ_CP012119:c1340681-1340511 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT55796 NZ_CP012119:c1340681-1340511 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1