Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 480480..481159 Replicon chromosome
Accession NZ_CP012117
Organism Dermabacter vaginalis strain AD1-86

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B0ZG69
Locus tag DAD186_RS01905 Protein ID WP_065247278.1
Coordinates 480480..480875 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B0ZG85
Locus tag DAD186_RS01910 Protein ID WP_065247279.1
Coordinates 480872..481159 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAD186_RS01900 478231..480345 + 2115 WP_065247277.1 5'-nucleotidase C-terminal domain-containing protein -
DAD186_RS01905 480480..480875 - 396 WP_065247278.1 type II toxin-antitoxin system VapC family toxin Toxin
DAD186_RS01910 480872..481159 - 288 WP_065247279.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DAD186_RS01915 481419..482984 + 1566 WP_065247280.1 MFS transporter -
DAD186_RS01920 483070..483717 + 648 WP_065248674.1 TetR family transcriptional regulator -
DAD186_RS01925 483744..485345 + 1602 WP_065247281.1 DUF853 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-53)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13911.95 Da        Isoelectric Point: 4.8944

>T55786 WP_065247278.1 NZ_CP012117:c480875-480480 [Dermabacter vaginalis]
MTVAPRIYVDTSALAKLLLGEPDSSALSSWLDASQTELVSSDLLETELRRIAVREGVEQKVATAILAGVSLATLDRTAFR
SAGLLPGKHLRTLDALHLESALRLGAAAMLTYDHRLAEACESVGLETIAPS

Download         Length: 396 bp

>T55786 NZ_CP012117:c480875-480480 [Dermabacter vaginalis]
ATGACTGTCGCGCCGCGAATCTATGTTGATACTTCCGCGTTGGCGAAGCTACTCCTCGGCGAACCGGATTCCTCCGCGCT
CAGTTCTTGGCTCGACGCTTCACAGACCGAACTCGTTTCGAGCGACCTGCTCGAAACTGAGCTGAGGCGGATCGCCGTTC
GCGAAGGCGTCGAGCAAAAAGTCGCCACGGCAATCCTCGCCGGGGTTTCACTCGCCACTTTGGATCGCACAGCCTTTCGG
AGCGCAGGCCTCTTGCCCGGGAAGCATCTTCGAACCCTCGATGCCCTCCATCTCGAAAGCGCTCTCCGCTTGGGTGCAGC
CGCCATGCTGACATACGATCACCGCCTCGCGGAAGCTTGCGAAAGCGTCGGCCTCGAGACCATCGCCCCCTCATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10459.80 Da        Isoelectric Point: 9.4464

>AT55786 WP_065247279.1 NZ_CP012117:c481159-480872 [Dermabacter vaginalis]
MSEALGIDRTLPQRELRNQSARVLRAVAAGESFVVTNRGEAVARLVPIDEQEPRLPITRPASRIGGWSDLVDSHVTSFPS
GRAQRALDDVRAERL

Download         Length: 288 bp

>AT55786 NZ_CP012117:c481159-480872 [Dermabacter vaginalis]
ATGAGCGAAGCACTCGGAATTGACCGTACCCTTCCGCAGCGTGAGCTAAGGAATCAATCCGCGCGCGTGCTACGCGCAGT
CGCTGCGGGCGAATCTTTCGTCGTCACGAATCGCGGCGAAGCTGTCGCTCGTCTCGTGCCCATCGACGAACAGGAACCTC
GCCTTCCGATCACGCGGCCCGCCTCGAGAATCGGCGGTTGGAGCGACCTCGTCGATTCCCACGTCACGTCCTTTCCGAGC
GGTCGCGCGCAGCGAGCATTAGATGACGTGCGGGCGGAACGACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B0ZG69

Antitoxin

Source ID Structure
AlphaFold DB A0A1B0ZG85

References