Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 694126..694709 Replicon chromosome
Accession NZ_CP012111
Organism Acetobacter pasteurianus strain Ab3

Toxin (Protein)


Gene name hicA Uniprot ID F1YT37
Locus tag DB34_RS03195 Protein ID WP_006116155.1
Coordinates 694455..694709 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID C7JFF6
Locus tag DB34_RS03190 Protein ID WP_012812714.1
Coordinates 694126..694458 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DB34_RS03170 689428..691653 - 2226 WP_050818746.1 hypothetical protein -
DB34_RS03175 692625..693036 - 412 Protein_604 RusA family crossover junction endodeoxyribonuclease -
DB34_RS03180 693474..693785 + 312 WP_050818748.1 hypothetical protein -
DB34_RS03185 693791..694084 + 294 WP_019088174.1 hypothetical protein -
DB34_RS03190 694126..694458 - 333 WP_012812714.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DB34_RS03195 694455..694709 - 255 WP_006116155.1 type II toxin-antitoxin system HicA family toxin Toxin
DB34_RS03200 694775..695713 - 939 WP_050818750.1 plasmid recombination protein -
DB34_RS03205 696001..697212 - 1212 WP_050818752.1 tyrosine-type recombinase/integrase -
DB34_RS03210 697439..699232 - 1794 WP_050818754.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9479.92 Da        Isoelectric Point: 10.3861

>T55785 WP_006116155.1 NZ_CP012111:c694709-694455 [Acetobacter pasteurianus]
MKAKHRRTLELIFKRPVSGNVPWADIEALFVSLGAEVSEREGSRIGVFLFDEVKVFHRPHPKPDTDKGAVASVRKWLEQN
GVTP

Download         Length: 255 bp

>T55785 NZ_CP012111:c694709-694455 [Acetobacter pasteurianus]
ATGAAAGCCAAGCACCGCCGCACATTGGAGTTGATTTTCAAACGTCCTGTTTCGGGCAATGTGCCATGGGCAGACATTGA
AGCTTTGTTTGTTTCTCTTGGGGCGGAGGTGTCTGAAAGAGAAGGCTCCCGCATAGGGGTGTTCCTGTTTGATGAGGTGA
AGGTGTTTCACAGACCTCACCCCAAACCGGATACCGACAAGGGTGCCGTAGCCTCTGTGCGAAAATGGCTTGAGCAGAAT
GGAGTGACGCCATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11962.61 Da        Isoelectric Point: 4.6856

>AT55785 WP_012812714.1 NZ_CP012111:c694458-694126 [Acetobacter pasteurianus]
MNNVMEIGGHRAVIQFDPEIGMFRGEFLGLNGGADFYADSVAGLQQEGEASLRVFMEMCAEKGIDPVKHYSGRFVVRLPE
EVHARAVEIAAARGVSLNRLVQDALAQVEG

Download         Length: 333 bp

>AT55785 NZ_CP012111:c694458-694126 [Acetobacter pasteurianus]
ATGAACAACGTAATGGAAATTGGCGGCCATCGGGCTGTTATTCAGTTTGATCCTGAAATCGGGATGTTTCGGGGCGAGTT
TCTGGGACTGAACGGAGGGGCTGATTTCTACGCAGATAGTGTGGCAGGCCTTCAGCAGGAAGGGGAAGCTTCCCTCCGTG
TATTCATGGAGATGTGCGCCGAAAAGGGCATTGATCCCGTGAAGCATTATTCAGGCCGGTTTGTTGTGAGATTGCCGGAA
GAGGTCCATGCACGGGCAGTCGAGATTGCTGCAGCACGTGGTGTCAGTCTTAACCGCCTAGTGCAGGATGCTCTGGCGCA
GGTTGAAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A401X5W6

Antitoxin

Source ID Structure
AlphaFold DB C7JFF6

References