Detailed information of TA system TA055783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2327758..2328736
• Replicon: chromosome
• Accession: NZ_CP012099
• Organism: Bacillus thuringiensis strain HS18-1

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: AC241_RS12125
• Protein ID: WP_016081623.1
• Coordinates: 2327758..2328495 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W8YZL5
• Locus tag: AC241_RS12130
• Protein ID: WP_000237818.1
• Coordinates: 2328608..2328736 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC241_RS12105	2323403..2324182	+	780	WP_155417059.1	class I SAM-dependent methyltransferase	-
AC241_RS12110	2324340..2326025	-	1686	WP_080990779.1	alpha-keto acid decarboxylase family protein	-
AC241_RS12115	2326133..2326615	+	483	WP_016081625.1	MarR family winged helix-turn-helix transcriptional regulator	-
AC241_RS12120	2326782..2327519	+	738	WP_016081624.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
AC241_RS12125	2327758..2328495	+	738	WP_016081623.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
AC241_RS12130	2328608..2328736	+	129	WP_000237818.1	hypothetical protein	Antitoxin
AC241_RS12135	2328809..2328985	+	177	WP_016081622.1	stage II sporulation protein SB	-
AC241_RS12140	2329005..2329394	-	390	WP_016081621.1	YxeA family protein	-
AC241_RS12145	2329606..2331075	+	1470	WP_050843601.1	beta-Ala-His dipeptidase	-
AC241_RS12150	2331321..2332130	+	810	WP_050843603.1	C39 family peptidase	-
AC241_RS12155	2332156..2332758	+	603	WP_050843605.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28351.09 Da
• Isoelectric Point: 8.2998

>T55783 WP_016081623.1 NZ_CP012099:2327758-2328495 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFTDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIIIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T55783 NZ_CP012099:2327758-2328495 [Bacillus thuringiensis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACTGTGTATTTCA
TGATAAAAGGAATCGACTTAACCCTCTGGAAAAATCTTTTGATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACACCTAATATTTCAGAAATATGGGGTGCGAAATTTACCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAACCCATCAGTATTCGGTACGATGG
AATGGCATACAGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGTGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAATTAAATACAAACTTTCGGGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTATTATTGATGGAAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 5011.40 Da
• Isoelectric Point: 3.9150

>AT55783 WP_000237818.1 NZ_CP012099:2328608-2328736 [Bacillus thuringiensis]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Nucleotide

• Length: 129 bp

>AT55783 NZ_CP012099:2328608-2328736 [Bacillus thuringiensis]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGACACAACCGATTTCTCTTTAATAAAAGGTGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Antitoxin

• AlphaFold DB: W8YZL5