55782

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239065..239707 Replicon chromosome
Accession NZ_CP012099
Organism Bacillus thuringiensis strain HS18-1

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag AC241_RS01385 Protein ID WP_000635965.1
Coordinates 239357..239707 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag AC241_RS01380 Protein ID WP_000004570.1
Coordinates 239065..239352 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC241_RS01355 234382..235344 + 963 WP_000961146.1 UV DNA damage repair endonuclease UvsE -
AC241_RS01360 235337..235909 - 573 WP_000908525.1 rhomboid family intramembrane serine protease -
AC241_RS01365 236003..236362 + 360 WP_000583418.1 holo-ACP synthase -
AC241_RS01370 236519..237469 + 951 WP_002094231.1 outer membrane lipoprotein carrier protein LolA -
AC241_RS01375 237587..238756 + 1170 WP_043937329.1 alanine racemase -
AC241_RS01380 239065..239352 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
AC241_RS01385 239357..239707 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AC241_RS01390 239776..241944 + 2169 WP_043937331.1 RNA-binding transcriptional accessory protein -
AC241_RS01395 242002..242118 - 117 WP_001143640.1 cortex morphogenetic protein CmpA -
AC241_RS01400 242314..242772 + 459 WP_016083957.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T55782 WP_000635965.1 NZ_CP012099:239357-239707 [Bacillus thuringiensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T55782 NZ_CP012099:239357-239707 [Bacillus thuringiensis]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTATGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTAGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT55782 WP_000004570.1 NZ_CP012099:239065-239352 [Bacillus thuringiensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT55782 NZ_CP012099:239065-239352 [Bacillus thuringiensis]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTATATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCG
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References