Detailed information of TA system TA055781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 2943968..2944475
• Replicon: chromosome
• Accession: NZ_CP012098
• Organism: Anaerostipes hadrus strain BPB5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DO83_RS14585
• Protein ID: WP_077327362.1
• Coordinates: 2943968..2944219 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: DO83_RS14590
• Protein ID: WP_077327365.1
• Coordinates: 2944212..2944475 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DO83_RS14565	2939067..2939270	+	204	Protein_2814	DUF3990 domain-containing protein	-
DO83_RS14570	2939716..2939877	+	162	Protein_2815	phage holin family protein	-
DO83_RS14575	2940355..2943521	+	3167	Protein_2816	response regulator	-
DO83_RS14585	2943968..2944219	-	252	WP_077327362.1	Txe/YoeB family addiction module toxin	Toxin
DO83_RS14590	2944212..2944475	-	264	WP_077327365.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DO83_RS14595	2945047..2946669	-	1623	WP_077325578.1	IS1182 family transposase	-
DO83_RS14600	2946775..2949012	-	2238	WP_077327368.1	UvrD-helicase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 10001.35 Da
• Isoelectric Point: 9.3455

>T55781 WP_077327362.1 NZ_CP012098:c2944219-2943968 [Anaerostipes hadrus]
MNKLFTDNGWKDYVYWQTEDRKTLKKINSLINDILRNGNVGMGKPEPLTSNLSGYWSRRINDKDRLIYRIDEENIYILSC
RYH

Nucleotide

• Length: 252 bp

>T55781 NZ_CP012098:c2944219-2943968 [Anaerostipes hadrus]
ATGAATAAATTGTTCACGGATAACGGATGGAAAGACTATGTATATTGGCAAACCGAGGACCGTAAAACCCTAAAAAAAAT
CAATTCACTAATAAATGATATTCTGAGAAATGGAAATGTTGGAATGGGCAAACCAGAACCTTTAACTAGTAATCTATCTG
GCTATTGGAGTCGACGAATTAATGATAAAGATCGTCTTATTTATCGAATTGATGAAGAAAATATTTATATTCTTTCTTGC
AGATATCATTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10404.61 Da
• Isoelectric Point: 4.3023

>AT55781 WP_077327365.1 NZ_CP012098:c2944475-2944212 [Anaerostipes hadrus]
MLAVNYTNFRENLKDYMDKATDDYETMIVTRKNNKNVVMISEESYNNLMENVYVMGNKSNYDWLMESKEQLESGKYTKHD
LIEVQDE

Nucleotide

• Length: 264 bp

>AT55781 NZ_CP012098:c2944475-2944212 [Anaerostipes hadrus]
ATGTTAGCAGTAAACTATACAAATTTTCGTGAAAATCTAAAGGATTATATGGATAAAGCAACAGATGATTATGAAACTAT
GATCGTTACACGTAAAAATAATAAAAATGTTGTTATGATTTCTGAAGAATCATACAATAATTTAATGGAAAATGTCTATG
TCATGGGAAACAAATCCAATTATGATTGGTTAATGGAATCTAAAGAACAATTAGAATCTGGAAAATATACAAAGCATGAT
CTTATTGAGGTGCAAGATGAATAA