Detailed information of TA system TA055780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE(toxin)
• Location: 5128202..5128767
• Replicon: chromosome
• Accession: NZ_CP012097
• Organism: Serratia plymuthica strain 3Re4-18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ADP73_RS23675
• Protein ID: WP_037433752.1
• Coordinates: 5128489..5128767 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: S4YTP6
• Locus tag: ADP73_RS23670
• Protein ID: WP_004951261.1
• Coordinates: 5128202..5128471 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADP73_RS23655	5124416..5125633	-	1218	WP_037433747.1	aspartate aminotransferase family protein	-
ADP73_RS23660	5125765..5126340	-	576	WP_006328493.1	aminodeoxychorismate synthase component II	-
ADP73_RS23665	5126446..5127972	-	1527	WP_064799215.1	DUF853 family protein	-
ADP73_RS23670	5128202..5128471	+	270	WP_004951261.1	hypothetical protein	Antitoxin
ADP73_RS23675	5128489..5128767	+	279	WP_037433752.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ADP73_RS23680	5128768..5129493	-	726	WP_004951264.1	two-component system response regulator BtsR	-
ADP73_RS23685	5129493..5131178	-	1686	WP_037433755.1	sensor histidine kinase	-
ADP73_RS23690	5131338..5131907	-	570	WP_006328507.1	peptidylprolyl isomerase A	-
ADP73_RS23695	5132263..5132601	+	339	WP_006328508.1	PTS lactose/cellobiose transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10290.90 Da
• Isoelectric Point: 8.5141

>T55780 WP_037433752.1 NZ_CP012097:5128489-5128767 [Serratia plymuthica]
VTLKWTEPAIADRMAIYDYLETKNPATAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Nucleotide

• Length: 279 bp

>T55780 NZ_CP012097:5128489-5128767 [Serratia plymuthica]
GTGACACTCAAGTGGACGGAACCCGCGATTGCCGATCGTATGGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCAC
AGCTATAGAAATTGATAGCTTGATTTCAGCAACTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGTCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTATTTTCTGGTTTATGAATTAATCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10364.70 Da
• Isoelectric Point: 7.0169

>AT55780 WP_004951261.1 NZ_CP012097:5128202-5128471 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Nucleotide

• Length: 270 bp

>AT55780 NZ_CP012097:5128202-5128471 [Serratia plymuthica]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCTGCCAAAGCAGCCGATCG
CACAGCATCTCAGTTGCTGCGTGATTTCATGCGTGATTTTGTCAGTCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TACAGGAAAAAGTGGACTTGAGCCGTAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCCGTTGAGGCCTACTTC
GCTGAGCGCAGGTCAAAACTGATAAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1B1KXK3