Detailed information of TA system TA055778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3217587..3218212
• Replicon: chromosome
• Accession: NZ_CP012097
• Organism: Serratia plymuthica strain 3Re4-18

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S4YKF9
• Locus tag: ADP73_RS25445
• Protein ID: WP_020439240.1
• Coordinates: 3217587..3217769 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: S4YHW4
• Locus tag: ADP73_RS15065
• Protein ID: WP_006326094.1
• Coordinates: 3217799..3218212 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADP73_RS25955	3213086..3213346	-	261	WP_145917155.1	hypothetical protein	-
ADP73_RS15060	3213449..3217420	+	3972	WP_006326092.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
ADP73_RS25445	3217587..3217769	+	183	WP_020439240.1	type II toxin-antitoxin system HicA family toxin	Toxin
ADP73_RS15065	3217799..3218212	+	414	WP_006326094.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ADP73_RS15070	3218245..3218997	-	753	WP_004945934.1	L-cystine ABC transporter ATP-binding protein YecC	-
ADP73_RS15075	3219001..3219663	-	663	WP_004945937.1	cystine ABC transporter permease	-
ADP73_RS15080	3219663..3220463	-	801	WP_006326095.1	cystine ABC transporter substrate-binding protein	-
ADP73_RS15085	3220577..3221569	-	993	WP_006326096.1	D-cysteine desulfhydrase	-
ADP73_RS15090	3221695..3222204	-	510	WP_004945946.1	flagella biosynthesis regulatory protein FliZ	-
ADP73_RS15095	3222261..3222983	-	723	WP_004945948.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6891.13 Da
• Isoelectric Point: 11.0382

>T55778 WP_020439240.1 NZ_CP012097:3217587-3217769 [Serratia plymuthica]
VKSAEPIRLLEREGWVLERIKGSHHQFKHPSSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T55778 NZ_CP012097:3217587-3217769 [Serratia plymuthica]
GTGAAAAGTGCAGAACCGATCAGGCTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
CAAACACCCGAGTTCCCGTCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGGCTGTGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15156.85 Da
• Isoelectric Point: 4.5728

>AT55778 WP_006326094.1 NZ_CP012097:3217799-3218212 [Serratia plymuthica]
MFYPAYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSVVQQHPGYGSRSAFLAAAARNELLKVD

Nucleotide

• Length: 414 bp

>AT55778 NZ_CP012097:3217799-3218212 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTAGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGGATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCAGTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTAT
TGAAAGTCGATTAG

Structures

Toxin

• AlphaFold DB: S4YKF9

Antitoxin

• AlphaFold DB: S4YHW4