Detailed information of TA system TA055769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1669539..1670092
• Replicon: chromosome
• Accession: NZ_CP012097
• Organism: Serratia plymuthica strain 3Re4-18

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: S4YH80
• Locus tag: ADP73_RS07905
• Protein ID: WP_020438747.1
• Coordinates: 1669778..1670092 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: S4YG56
• Locus tag: ADP73_RS07900
• Protein ID: WP_020438746.1
• Coordinates: 1669539..1669775 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADP73_RS07885	1665965..1667503	+	1539	WP_006324385.1	glutathione ABC transporter substrate-binding protein GsiB	-
ADP73_RS07890	1667556..1668476	+	921	WP_006324386.1	glutathione ABC transporter permease GsiC	-
ADP73_RS07895	1668486..1669394	+	909	WP_004942335.1	glutathione ABC transporter permease GsiD	-
ADP73_RS07900	1669539..1669775	+	237	WP_020438746.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
ADP73_RS07905	1669778..1670092	+	315	WP_020438747.1	CcdB family protein	Toxin
ADP73_RS07910	1670126..1670971	-	846	WP_006324390.1	S-formylglutathione hydrolase	-
ADP73_RS07915	1670986..1672113	-	1128	WP_004942340.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
ADP73_RS07920	1672142..1673059	-	918	WP_004942342.1	LysR family transcriptional regulator	-
ADP73_RS07925	1673167..1674324	+	1158	WP_006324392.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11685.58 Da
• Isoelectric Point: 5.8036

>T55769 WP_020438747.1 NZ_CP012097:1669778-1670092 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGI

Nucleotide

• Length: 315 bp

>T55769 NZ_CP012097:1669778-1670092 [Serratia plymuthica]
ATGCAATTTACGGTATACGCGAATACAGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGCCGAGTTGTGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACCCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9078.16 Da
• Isoelectric Point: 6.7184

>AT55769 WP_020438746.1 NZ_CP012097:1669539-1669775 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEENREAIDALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT55769 NZ_CP012097:1669539-1669775 [Serratia plymuthica]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGGTGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTGCTACGCTGAATGCTGCTTTGGATGCAGAATTGCGTCAGCATGAGATGAGAAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGATGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Structures

Toxin

• AlphaFold DB: S4YH80

Antitoxin

• AlphaFold DB: S4YG56