Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1180398..1181020 Replicon chromosome
Accession NZ_CP012097
Organism Serratia plymuthica strain 3Re4-18

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag ADP73_RS05470 Protein ID WP_006322256.1
Coordinates 1180398..1180601 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag ADP73_RS05475 Protein ID WP_004949348.1
Coordinates 1180652..1181020 (-) Length 123 a.a.

Genomic Context

ADP73_RS05445ADP73_RS05450ADP73_RS05460ADP73_RS05465ADP73_RS05490ADP73_RS05495ADP73_RS05500ADP73_RS05455ADP73_RS05470ADP73_RS05475ADP73_RS05480ADP73_RS05505ADP73_RS05510
Location: 1176165..1176626 (462 bp)
Type: Others
Protein ID: WP_006323963.1
Location: 1176659..1177489 (831 bp)
Type: Others
Protein ID: WP_064798676.1
Location: 1178140..1179561 (1422 bp)
Type: Others
Protein ID: WP_064798677.1
Location: 1179622..1180158 (537 bp)
Type: Others
Protein ID: WP_006323971.1
Location: 1181985..1182698 (714 bp)
Type: Others
Protein ID: WP_006323974.1
Location: 1182695..1183552 (858 bp)
Type: Others
Protein ID: WP_004949351.1
Location: 1183578..1184456 (879 bp)
Type: Others
Protein ID: WP_006323980.1
Location: 1177486..1177860 (375 bp)
Type: Others
Protein ID: WP_006323969.1
Location: 1180398..1180601 (204 bp)
Type: Toxin
Protein ID: WP_006322256.1
Location: 1180652..1181020 (369 bp)
Type: Antitoxin
Protein ID: WP_004949348.1
Location: 1181180..1181533 (354 bp)
Type: Others
Protein ID: WP_064798678.1
Location: 1184571..1184711 (141 bp)
Type: Others
Protein ID: WP_004949353.1
Location: 1184724..1184978 (255 bp)
Type: Others
Protein ID: WP_004949355.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ADP73_RS054451176165..1176626+462WP_006323963.1type II secretion system protein M-
ADP73_RS054501176659..1177489+831WP_064798676.1A24 family peptidase-
ADP73_RS054551177486..1177860-375WP_006323969.1type II secretion system pilot lipoprotein GspS-
ADP73_RS054601178140..1179561+1422WP_064798677.1N-acetylglucosamine-binding protein GbpA-
ADP73_RS054651179622..1180158+537WP_006323971.1cytochrome b/b6 domain-containing protein-
ADP73_RS054701180398..1180601-204WP_006322256.1hemolysin expression modulator HhaToxin
ADP73_RS054751180652..1181020-369WP_004949348.1Hha toxicity modulator TomBAntitoxin
ADP73_RS054801181180..1181533-354WP_064798678.1hypothetical protein-
ADP73_RS054901181985..1182698+714WP_006323974.1ABC transporter ATP-binding protein-
ADP73_RS054951182695..1183552+858WP_004949351.1metal ABC transporter permease-
ADP73_RS055001183578..1184456+879WP_006323980.1metal ABC transporter substrate-binding protein-
ADP73_RS055051184571..1184711-141WP_004949353.1type B 50S ribosomal protein L36-
ADP73_RS055101184724..1184978-255WP_004949355.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T55768 WP_006322256.1 NZ_CP012097:c1180601-1180398 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T55768 NZ_CP012097:c1180601-1180398 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT55768 WP_004949348.1 NZ_CP012097:c1181020-1180652 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT55768 NZ_CP012097:c1181020-1180652 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACGCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1KM53

Antitoxin

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Source
ID
Structure
AlphaFold DBS4YKH5

References