Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1180398..1181020 Replicon chromosome
Accession NZ_CP012097
Organism Serratia plymuthica strain 3Re4-18

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag ADP73_RS05470 Protein ID WP_006322256.1
Coordinates 1180398..1180601 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag ADP73_RS05475 Protein ID WP_004949348.1
Coordinates 1180652..1181020 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADP73_RS05445 1176165..1176626 + 462 WP_006323963.1 type II secretion system protein M -
ADP73_RS05450 1176659..1177489 + 831 WP_064798676.1 A24 family peptidase -
ADP73_RS05455 1177486..1177860 - 375 WP_006323969.1 type II secretion system pilot lipoprotein GspS -
ADP73_RS05460 1178140..1179561 + 1422 WP_064798677.1 N-acetylglucosamine-binding protein GbpA -
ADP73_RS05465 1179622..1180158 + 537 WP_006323971.1 cytochrome b/b6 domain-containing protein -
ADP73_RS05470 1180398..1180601 - 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
ADP73_RS05475 1180652..1181020 - 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
ADP73_RS05480 1181180..1181533 - 354 WP_064798678.1 hypothetical protein -
ADP73_RS05490 1181985..1182698 + 714 WP_006323974.1 ABC transporter ATP-binding protein -
ADP73_RS05495 1182695..1183552 + 858 WP_004949351.1 metal ABC transporter permease -
ADP73_RS05500 1183578..1184456 + 879 WP_006323980.1 metal ABC transporter substrate-binding protein -
ADP73_RS05505 1184571..1184711 - 141 WP_004949353.1 type B 50S ribosomal protein L36 -
ADP73_RS05510 1184724..1184978 - 255 WP_004949355.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T55768 WP_006322256.1 NZ_CP012097:c1180601-1180398 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T55768 NZ_CP012097:c1180601-1180398 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT55768 WP_004949348.1 NZ_CP012097:c1181020-1180652 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT55768 NZ_CP012097:c1181020-1180652 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACGCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References