Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 565015..566638 Replicon chromosome
Accession NZ_CP012097
Organism Serratia plymuthica strain 3Re4-18

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ADP73_RS02600 Protein ID WP_064798625.1
Coordinates 565316..566638 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ADP73_RS02595 Protein ID WP_064798624.1
Coordinates 565015..565311 (+) Length 99 a.a.

Genomic Context

ADP73_RS02575ADP73_RS02580ADP73_RS02590ADP73_RS02595ADP73_RS02600ADP73_RS02605ADP73_RS02610ADP73_RS25790ADP73_RS25785ADP73_RS02585ADP73_RS25795ADP73_RS02620
Location: 561874..562011 (138 bp)
Type: Others
Protein ID: WP_100220743.1
Location: 561995..562317 (323 bp)
Type: Others
Protein ID: Protein_491
Location: 564172..564807 (636 bp)
Type: Others
Protein ID: WP_006323372.1
Location: 565015..565311 (297 bp)
Type: Antitoxin
Protein ID: WP_064798624.1
Location: 565316..566638 (1323 bp)
Type: Toxin
Protein ID: WP_064798625.1
Location: 566821..567783 (963 bp)
Type: Others
Protein ID: WP_064798626.1
Location: 567902..568435 (534 bp)
Type: Others
Protein ID: WP_064799248.1
Location: 568428..568580 (153 bp)
Type: Others
Protein ID: WP_203227789.1
Location: 560886..561164 (279 bp)
Type: Others
Protein ID: WP_144080223.1
Location: 562630..563190 (561 bp)
Type: Others
Protein ID: WP_006323369.1
Location: 568938..569600 (663 bp)
Type: Others
Protein ID: WP_145917138.1
Location: 569593..570222 (630 bp)
Type: Others
Protein ID: WP_064798628.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ADP73_RS25785560886..561164-279WP_144080223.1hypothetical protein-
ADP73_RS02575561874..562011+138WP_100220743.1type II toxin-antitoxin system RelE/ParE family toxin-
ADP73_RS02580561995..562317+323Protein_491DNA-binding transcriptional regulator-
ADP73_RS02585562630..563190-561WP_006323369.1hypothetical protein-
ADP73_RS02590564172..564807+636WP_006323372.1carbonic anhydrase-
ADP73_RS02595565015..565311+297WP_064798624.1helix-turn-helix transcriptional regulatorAntitoxin
ADP73_RS02600565316..566638+1323WP_064798625.1type II toxin-antitoxin system HipA family toxinToxin
ADP73_RS02605566821..567783+963WP_064798626.1toll/interleukin-1 receptor domain-containing protein-
ADP73_RS02610567902..568435+534WP_064799248.1hypothetical protein-
ADP73_RS25790568428..568580+153WP_203227789.1hypothetical protein-
ADP73_RS25795568938..569600-663WP_145917138.1hypothetical protein-
ADP73_RS02620569593..570222-630WP_064798628.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49841.87 Da        Isoelectric Point: 6.6325

>T55766 WP_064798625.1 NZ_CP012097:565316-566638 [Serratia plymuthica]
MRRSQQRLAIWMNSIPVGYWEKRKGEDRLEYLPGWIADNQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRYHAESLDPFDLLAELGRDCVGAIQLLDIDEQPTHIFSIRQRPLSEAQIAEMLRNTATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDGQWWIRLPQEDMCQALGVSPLKKYQSDGGPGITDIMEVLSRSDQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNSQIAWQKCKLAMAVRGSSNYYHISQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIDRVAGLLPDSFPPELAACIFDGIRQQCARLAGR

Download         Length: 1323 bp

>T55766 NZ_CP012097:565316-566638 [Serratia plymuthica]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAATAGTATTCCGGTGGGATACTGGGAAAAGCGCAAAGGTGAAGA
TCGGCTGGAATATCTGCCTGGTTGGATTGCAGATAACCAGGGGAGACCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ATCAGCCTTATCGTGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGAGGGGATCCGCCGACGTCTG
GCAATGCGTTATCATGCCGAAAGCCTTGATCCCTTTGATTTACTGGCTGAACTGGGCCGTGACTGTGTTGGTGCCATACA
ACTTCTTGATATTGATGAGCAACCCACCCATATATTTTCCATCAGGCAGCGCCCGCTTTCAGAGGCGCAAATTGCCGAAA
TGCTCCGCAATACTGCCACGATGTTACCGGGGCGACAGGGTCAGGATGACGATCTGCGCTTATCCATCGCCGGCGCTCAG
GAAAAAACAGCGCTGTTGTGGCACGACAACCAGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATATTTAAATT
AGCGCTGGGGCTGGTGGGGAATATGCGGGCCGATATGAGCACATCCATCGAGAATGAATGGCTCTGCTCTCTGATTCTTG
AACACTATGGTGTGCCTGTCGCAAGAACGGCTATTGCGCAGTTTGAAGATCAAAAGGCGCTGATCGTTGAGCGTTTTGAC
AGGAAGCTATCAAGTGATGGGCAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAAGAAGTATCAGTCAGACGGTGGCCCCGGTATTACAGATATTATGGAAGTTCTGAGTCGCTCGGATCAGGCTGAAACAG
ATCGCAGGCACTTCTTTAAGGCGCAGATTATTTTTTGGTTGCTGGCCGCGACCGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCGCAAAATCGTTACCACCTGACGCCCCTGTACGATGTGTTATCGGCCTGGCCGCTGATTGGCCCGGGGAA
TAGCCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAACTATTACCACATTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGGTTAGGCCAACAGGAAGTTGAATCCATTATTGAAGAGCTGCTG
GCGGCGACCCCGGGAGTTATTGATCGTGTCGCTGGACTGCTGCCTGATTCGTTTCCGCCTGAATTAGCGGCATGCATTTT
TGATGGTATCAGGCAGCAGTGTGCGCGGTTGGCAGGGCGATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11009.49 Da        Isoelectric Point: 8.5849

>AT55766 WP_064798624.1 NZ_CP012097:565015-565311 [Serratia plymuthica]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEVVLSSELTSPGFE
TEDTSTTHIDSPARREQW

Download         Length: 297 bp

>AT55766 NZ_CP012097:565015-565311 [Serratia plymuthica]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAGCTACGCCCTTTACTGGTGGGTTTTCGTAAAGCGAAAGGTCTGAC
GCAAAAAGACGTCTCTGAGAGGCTGGGCGTCACCCAGCAGACCTACGCACGCCTGGAGTCAAACCCCGCTTCAGCCAGCC
TGGAACGCCTGTTTCGGGTGTTTAATGTGCTGGGCATTGAAGTGGTGCTTTCCTCAGAGCTGACCTCTCCGGGATTTGAA
ACGGAGGATACCTCTACAACTCATATAGACTCGCCCGCCAGGCGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References