Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 565015..566638 Replicon chromosome
Accession NZ_CP012097
Organism Serratia plymuthica strain 3Re4-18

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ADP73_RS02600 Protein ID WP_064798625.1
Coordinates 565316..566638 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ADP73_RS02595 Protein ID WP_064798624.1
Coordinates 565015..565311 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADP73_RS25785 560886..561164 - 279 WP_144080223.1 hypothetical protein -
ADP73_RS02575 561874..562011 + 138 WP_100220743.1 type II toxin-antitoxin system RelE/ParE family toxin -
ADP73_RS02580 561995..562317 + 323 Protein_491 DNA-binding transcriptional regulator -
ADP73_RS02585 562630..563190 - 561 WP_006323369.1 hypothetical protein -
ADP73_RS02590 564172..564807 + 636 WP_006323372.1 carbonic anhydrase -
ADP73_RS02595 565015..565311 + 297 WP_064798624.1 helix-turn-helix transcriptional regulator Antitoxin
ADP73_RS02600 565316..566638 + 1323 WP_064798625.1 type II toxin-antitoxin system HipA family toxin Toxin
ADP73_RS02605 566821..567783 + 963 WP_064798626.1 toll/interleukin-1 receptor domain-containing protein -
ADP73_RS02610 567902..568435 + 534 WP_064799248.1 hypothetical protein -
ADP73_RS25790 568428..568580 + 153 WP_203227789.1 hypothetical protein -
ADP73_RS25795 568938..569600 - 663 WP_145917138.1 hypothetical protein -
ADP73_RS02620 569593..570222 - 630 WP_064798628.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49841.87 Da        Isoelectric Point: 6.6325

>T55766 WP_064798625.1 NZ_CP012097:565316-566638 [Serratia plymuthica]
MRRSQQRLAIWMNSIPVGYWEKRKGEDRLEYLPGWIADNQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRYHAESLDPFDLLAELGRDCVGAIQLLDIDEQPTHIFSIRQRPLSEAQIAEMLRNTATMLPGRQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSIENEWLCSLILEHYGVPVARTAIAQFEDQKALIVERFD
RKLSSDGQWWIRLPQEDMCQALGVSPLKKYQSDGGPGITDIMEVLSRSDQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNSQIAWQKCKLAMAVRGSSNYYHISQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIDRVAGLLPDSFPPELAACIFDGIRQQCARLAGR

Download         Length: 1323 bp

>T55766 NZ_CP012097:565316-566638 [Serratia plymuthica]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAATAGTATTCCGGTGGGATACTGGGAAAAGCGCAAAGGTGAAGA
TCGGCTGGAATATCTGCCTGGTTGGATTGCAGATAACCAGGGGAGACCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ATCAGCCTTATCGTGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGAGGGGATCCGCCGACGTCTG
GCAATGCGTTATCATGCCGAAAGCCTTGATCCCTTTGATTTACTGGCTGAACTGGGCCGTGACTGTGTTGGTGCCATACA
ACTTCTTGATATTGATGAGCAACCCACCCATATATTTTCCATCAGGCAGCGCCCGCTTTCAGAGGCGCAAATTGCCGAAA
TGCTCCGCAATACTGCCACGATGTTACCGGGGCGACAGGGTCAGGATGACGATCTGCGCTTATCCATCGCCGGCGCTCAG
GAAAAAACAGCGCTGTTGTGGCACGACAACCAGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATATTTAAATT
AGCGCTGGGGCTGGTGGGGAATATGCGGGCCGATATGAGCACATCCATCGAGAATGAATGGCTCTGCTCTCTGATTCTTG
AACACTATGGTGTGCCTGTCGCAAGAACGGCTATTGCGCAGTTTGAAGATCAAAAGGCGCTGATCGTTGAGCGTTTTGAC
AGGAAGCTATCAAGTGATGGGCAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAAGAAGTATCAGTCAGACGGTGGCCCCGGTATTACAGATATTATGGAAGTTCTGAGTCGCTCGGATCAGGCTGAAACAG
ATCGCAGGCACTTCTTTAAGGCGCAGATTATTTTTTGGTTGCTGGCCGCGACCGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCGCAAAATCGTTACCACCTGACGCCCCTGTACGATGTGTTATCGGCCTGGCCGCTGATTGGCCCGGGGAA
TAGCCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAACTATTACCACATTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGGTTAGGCCAACAGGAAGTTGAATCCATTATTGAAGAGCTGCTG
GCGGCGACCCCGGGAGTTATTGATCGTGTCGCTGGACTGCTGCCTGATTCGTTTCCGCCTGAATTAGCGGCATGCATTTT
TGATGGTATCAGGCAGCAGTGTGCGCGGTTGGCAGGGCGATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11009.49 Da        Isoelectric Point: 8.5849

>AT55766 WP_064798624.1 NZ_CP012097:565015-565311 [Serratia plymuthica]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEVVLSSELTSPGFE
TEDTSTTHIDSPARREQW

Download         Length: 297 bp

>AT55766 NZ_CP012097:565015-565311 [Serratia plymuthica]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAGCTACGCCCTTTACTGGTGGGTTTTCGTAAAGCGAAAGGTCTGAC
GCAAAAAGACGTCTCTGAGAGGCTGGGCGTCACCCAGCAGACCTACGCACGCCTGGAGTCAAACCCCGCTTCAGCCAGCC
TGGAACGCCTGTTTCGGGTGTTTAATGTGCTGGGCATTGAAGTGGTGCTTTCCTCAGAGCTGACCTCTCCGGGATTTGAA
ACGGAGGATACCTCTACAACTCATATAGACTCGCCCGCCAGGCGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References