Detailed information of TA system TA055765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4629424..4630049
• Replicon: chromosome
• Accession: NZ_CP012096
• Organism: Serratia plymuthica strain 3Rp8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S4YKF9
• Locus tag: ADP72_RS21485
• Protein ID: WP_020439240.1
• Coordinates: 4629867..4630049 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: S4YHW4
• Locus tag: ADP72_RS21480
• Protein ID: WP_006326094.1
• Coordinates: 4629424..4629837 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADP72_RS21450	4624653..4625375	+	723	WP_004945948.1	RNA polymerase sigma factor FliA	-
ADP72_RS21455	4625432..4625941	+	510	WP_004945946.1	flagella biosynthesis regulatory protein FliZ	-
ADP72_RS21460	4626067..4627059	+	993	WP_006326096.1	D-cysteine desulfhydrase	-
ADP72_RS21465	4627173..4627973	+	801	WP_006326095.1	cystine ABC transporter substrate-binding protein	-
ADP72_RS21470	4627973..4628635	+	663	WP_004945937.1	cystine ABC transporter permease	-
ADP72_RS21475	4628639..4629391	+	753	WP_004945934.1	L-cystine ABC transporter ATP-binding protein YecC	-
ADP72_RS21480	4629424..4629837	-	414	WP_006326094.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ADP72_RS21485	4629867..4630049	-	183	WP_020439240.1	type II toxin-antitoxin system HicA family toxin	Toxin
ADP72_RS21490	4630216..4634187	-	3972	WP_006326092.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
ADP72_RS26680	4634290..4634550	+	261	WP_145917155.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (7-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6891.13 Da
• Isoelectric Point: 11.0382

>T55765 WP_020439240.1 NZ_CP012096:c4630049-4629867 [Serratia plymuthica]
VKSAEPIRLLEREGWVLERIKGSHHQFKHPSSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T55765 NZ_CP012096:c4630049-4629867 [Serratia plymuthica]
GTGAAAAGTGCAGAACCGATCAGGCTGTTAGAACGGGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
CAAACACCCGAGTTCCCGTCTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAAATCA
TGAAAGATGCCGGGCTGTGCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15156.85 Da
• Isoelectric Point: 4.5728

>AT55765 WP_006326094.1 NZ_CP012096:c4629837-4629424 [Serratia plymuthica]
MFYPAYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSVVQQHPGYGSRSAFLAAAARNELLKVD

Nucleotide

• Length: 414 bp

>AT55765 NZ_CP012096:c4629837-4629424 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACTACGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGACACCCTAGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGACGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATCCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACGCCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGGATAAATATCACCCTGCCGCACCGCTTGCTGAACCG
CATCGATTCAGTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCAGCCGCCCGTAATGAATTAT
TGAAAGTCGATTAG

Structures

Toxin

• AlphaFold DB: S4YKF9

Antitoxin

• AlphaFold DB: S4YHW4