Detailed information of TA system TA055764

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3362765..3363434
• Replicon: chromosome
• Accession: NZ_CP012096
• Organism: Serratia plymuthica strain 3Rp8

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: ADP72_RS15705
• Protein ID: WP_006327725.1
• Coordinates: 3363012..3363434 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: ADP72_RS15700
• Protein ID: WP_004952428.1
• Coordinates: 3362765..3363031 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADP72_RS15675	3357891..3359216	+	1326	WP_064799702.1	MHS family MFS transporter	-
ADP72_RS15680	3359264..3359872	-	609	WP_004952444.1	HD domain-containing protein	-
ADP72_RS15685	3360063..3360740	+	678	WP_037433581.1	hemolysin III family protein	-
ADP72_RS15690	3360903..3361400	+	498	WP_006327727.1	DUF2165 domain-containing protein	-
ADP72_RS15695	3361454..3362440	-	987	WP_006327726.1	tRNA-modifying protein YgfZ	-
ADP72_RS15700	3362765..3363031	+	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
ADP72_RS15705	3363012..3363434	+	423	WP_006327725.1	protein YgfX	Toxin
ADP72_RS15710	3363434..3364129	+	696	WP_004952420.1	two-component system response regulator CreB	-
ADP72_RS15715	3364126..3365544	+	1419	WP_006327719.1	two-component system sensor histidine kinase CreC	-
ADP72_RS15720	3365629..3366993	+	1365	WP_004952415.1	cell envelope integrity protein CreD	-
ADP72_RS15725	3367031..3367549	-	519	WP_004952413.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T55764 WP_006327725.1 NZ_CP012096:3363012-3363434 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T55764 NZ_CP012096:3363012-3363434 [Serratia plymuthica]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGCTACTCTCGCTGCTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCGCGGCAGGGCGAACTGCGTCTGCTGGCGAATAAGCGTTTAAGTTGGCACGGACAG
GAATGGTTGCTGGCAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGACGCAGGGCAAAAAACG
CCGCCGGCTATGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT55764 WP_004952428.1 NZ_CP012096:3362765-3363031 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT55764 NZ_CP012096:3362765-3363031 [Serratia plymuthica]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGATATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGACCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10