Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 2683322..2683893 Replicon chromosome
Accession NZ_CP012096
Organism Serratia plymuthica strain 3Rp8

Toxin (Protein)


Gene name relE Uniprot ID S4YNR1
Locus tag ADP72_RS12670 Protein ID WP_020439916.1
Coordinates 2683322..2683600 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S4YTP6
Locus tag ADP72_RS12675 Protein ID WP_004951261.1
Coordinates 2683624..2683893 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADP72_RS12650 2679488..2679826 - 339 WP_006328508.1 PTS lactose/cellobiose transporter subunit IIA -
ADP72_RS12655 2680182..2680751 + 570 WP_006328507.1 peptidylprolyl isomerase A -
ADP72_RS12660 2680911..2682596 + 1686 WP_006328506.1 sensor histidine kinase -
ADP72_RS12665 2682596..2683321 + 726 WP_004951264.1 two-component system response regulator BtsR -
ADP72_RS12670 2683322..2683600 - 279 WP_020439916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ADP72_RS12675 2683624..2683893 - 270 WP_004951261.1 hypothetical protein Antitoxin
ADP72_RS12680 2684123..2685649 + 1527 WP_006328494.1 DUF853 family protein -
ADP72_RS12685 2685755..2686330 + 576 WP_006328493.1 aminodeoxychorismate synthase component II -
ADP72_RS12690 2686462..2687679 + 1218 WP_037433747.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10242.84 Da        Isoelectric Point: 8.5141

>T55763 WP_020439916.1 NZ_CP012096:c2683600-2683322 [Serratia plymuthica]
VTLKWTEPAIADRIAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T55763 NZ_CP012096:c2683600-2683322 [Serratia plymuthica]
GTGACACTCAAGTGGACGGAACCCGCAATTGCCGATCGTATAGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCTATAGAAATTGATAGCTTGATTTCAGCAACTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGTCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTATTTTCTGGTTTATGAATTAATCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10364.70 Da        Isoelectric Point: 7.0169

>AT55763 WP_004951261.1 NZ_CP012096:c2683893-2683624 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Download         Length: 270 bp

>AT55763 NZ_CP012096:c2683893-2683624 [Serratia plymuthica]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCTGCCAAAGCAGCCGATCG
CACCGCATCTCAGTTGCTGCGCGATTTCATGCGTGATTTTGTCAGCCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TACAGGAAAAAGTGGACTTAAGCCGTAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCCGTTGAGGCCTACTTC
GCTGAACGTAGATCAAAACTGATAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4YNR1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KXK3

References