Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1179541..1180163 Replicon chromosome
Accession NZ_CP012096
Organism Serratia plymuthica strain 3Rp8

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag ADP72_RS05785 Protein ID WP_006322256.1
Coordinates 1179960..1180163 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag ADP72_RS05780 Protein ID WP_004949348.1
Coordinates 1179541..1179909 (+) Length 123 a.a.

Genomic Context

ADP72_RS05745ADP72_RS05750ADP72_RS05775ADP72_RS05780ADP72_RS05785ADP72_RS05800ADP72_RS05755ADP72_RS05760ADP72_RS05765ADP72_RS26865ADP72_RS05790ADP72_RS05795ADP72_RS05805ADP72_RS05810
Location: 1175583..1175837 (255 bp)
Type: Others
Protein ID: WP_004949355.1
Location: 1175850..1175990 (141 bp)
Type: Others
Protein ID: WP_004949353.1
Location: 1179028..1179381 (354 bp)
Type: Others
Protein ID: WP_004949349.1
Location: 1179541..1179909 (369 bp)
Type: Antitoxin
Protein ID: WP_004949348.1
Location: 1179960..1180163 (204 bp)
Type: Toxin
Protein ID: WP_006322256.1
Location: 1182701..1183075 (375 bp)
Type: Others
Protein ID: WP_062793130.1
Location: 1176105..1176983 (879 bp)
Type: Others
Protein ID: WP_006323980.1
Location: 1177009..1177866 (858 bp)
Type: Others
Protein ID: WP_004949351.1
Location: 1177863..1178576 (714 bp)
Type: Others
Protein ID: WP_064799499.1
Location: 1178573..1178722 (150 bp)
Type: Others
Protein ID: WP_006323973.1
Location: 1180403..1180939 (537 bp)
Type: Others
Protein ID: WP_006323971.1
Location: 1181000..1182421 (1422 bp)
Type: Others
Protein ID: WP_064799500.1
Location: 1183072..1183902 (831 bp)
Type: Others
Protein ID: WP_064799501.1
Location: 1183935..1184396 (462 bp)
Type: Others
Protein ID: WP_006323963.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ADP72_RS057451175583..1175837+255WP_004949355.1type B 50S ribosomal protein L31-
ADP72_RS057501175850..1175990+141WP_004949353.1type B 50S ribosomal protein L36-
ADP72_RS057551176105..1176983-879WP_006323980.1metal ABC transporter substrate-binding protein-
ADP72_RS057601177009..1177866-858WP_004949351.1metal ABC transporter permease-
ADP72_RS057651177863..1178576-714WP_064799499.1ABC transporter ATP-binding protein-
ADP72_RS268651178573..1178722-150WP_006323973.1hypothetical protein-
ADP72_RS057751179028..1179381+354WP_004949349.1hypothetical protein-
ADP72_RS057801179541..1179909+369WP_004949348.1Hha toxicity modulator TomBAntitoxin
ADP72_RS057851179960..1180163+204WP_006322256.1hemolysin expression modulator HhaToxin
ADP72_RS057901180403..1180939-537WP_006323971.1cytochrome b/b6 domain-containing protein-
ADP72_RS057951181000..1182421-1422WP_064799500.1N-acetylglucosamine-binding protein GbpA-
ADP72_RS058001182701..1183075+375WP_062793130.1type II secretion system pilot lipoprotein GspS-
ADP72_RS058051183072..1183902-831WP_064799501.1A24 family peptidase-
ADP72_RS058101183935..1184396-462WP_006323963.1type II secretion system protein M-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T55762 WP_006322256.1 NZ_CP012096:1179960-1180163 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T55762 NZ_CP012096:1179960-1180163 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT55762 WP_004949348.1 NZ_CP012096:1179541-1179909 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT55762 NZ_CP012096:1179541-1179909 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACGCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1KM53

Antitoxin

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Source
ID
Structure
AlphaFold DBS4YKH5

References