55762

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1179541..1180163 Replicon chromosome
Accession NZ_CP012096
Organism Serratia plymuthica strain 3Rp8

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag ADP72_RS05785 Protein ID WP_006322256.1
Coordinates 1179960..1180163 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag ADP72_RS05780 Protein ID WP_004949348.1
Coordinates 1179541..1179909 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADP72_RS05745 1175583..1175837 + 255 WP_004949355.1 type B 50S ribosomal protein L31 -
ADP72_RS05750 1175850..1175990 + 141 WP_004949353.1 type B 50S ribosomal protein L36 -
ADP72_RS05755 1176105..1176983 - 879 WP_006323980.1 metal ABC transporter substrate-binding protein -
ADP72_RS05760 1177009..1177866 - 858 WP_004949351.1 metal ABC transporter permease -
ADP72_RS05765 1177863..1178576 - 714 WP_064799499.1 ABC transporter ATP-binding protein -
ADP72_RS26865 1178573..1178722 - 150 WP_006323973.1 hypothetical protein -
ADP72_RS05775 1179028..1179381 + 354 WP_004949349.1 hypothetical protein -
ADP72_RS05780 1179541..1179909 + 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
ADP72_RS05785 1179960..1180163 + 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
ADP72_RS05790 1180403..1180939 - 537 WP_006323971.1 cytochrome b/b6 domain-containing protein -
ADP72_RS05795 1181000..1182421 - 1422 WP_064799500.1 N-acetylglucosamine-binding protein GbpA -
ADP72_RS05800 1182701..1183075 + 375 WP_062793130.1 type II secretion system pilot lipoprotein GspS -
ADP72_RS05805 1183072..1183902 - 831 WP_064799501.1 A24 family peptidase -
ADP72_RS05810 1183935..1184396 - 462 WP_006323963.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T55762 WP_006322256.1 NZ_CP012096:1179960-1180163 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T55762 NZ_CP012096:1179960-1180163 [Serratia plymuthica]
ATGACTAAAATTGACTATCTGATGCGTTTACGTAAATGCACCACGATTGACACCCTGGAACGCGTTATTGAAAAAAATAA
GTATGAGCTTTCGGATGACGAACTAGAGCTGTTCTACTCTGCAGCGGACCACCGTTTGGCCGAGCTCACCATGAATAAGC
TGTACGATAAAATCCCCGTTGCCGTTTGGAAATTCGTACGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT55762 WP_004949348.1 NZ_CP012096:1179541-1179909 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT55762 NZ_CP012096:1179541-1179909 [Serratia plymuthica]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
AACGCTGGGCGACAGCCACCACGGCTGGGTGAACGATCCAACGTCTTCCGTCAACCTCCAGCTTAACGAGTTGATTGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGTGATTTATCGGAGTTAGTCGAAGAGTATCTC
GACGATACCTACACGCTGTTTAGCAGTTATGGTATTAATGATTCCGATTTGCGCCGCTGGCAAAAAACCAAAGCGCGATT
ATTCAGAATGTTCTCAGGAGAGGGCATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References