Detailed information of TA system TA055760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 509115..509710
• Replicon: chromosome
• Accession: NZ_CP012096
• Organism: Serratia plymuthica strain 3Rp8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: ADP72_RS25705
• Protein ID: WP_071605322.1
• Coordinates: 509456..509710 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ADP72_RS02465
• Protein ID: WP_037433916.1
• Coordinates: 509115..509456 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADP72_RS02445	504581..505396	-	816	WP_064799400.1	GPO family capsid scaffolding protein	-
ADP72_RS02450	505539..507311	+	1773	WP_064799401.1	terminase ATPase subunit family protein	-
ADP72_RS02455	507311..508336	+	1026	WP_064799402.1	phage portal protein	-
ADP72_RS02460	508367..509056	-	690	WP_037432543.1	DUF4145 domain-containing protein	-
ADP72_RS02465	509115..509456	-	342	WP_037433916.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ADP72_RS25705	509456..509710	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
ADP72_RS02470	510379..511197	+	819	WP_037432540.1	hypothetical protein	-
ADP72_RS02480	511598..511795	-	198	WP_037432537.1	hypothetical protein	-
ADP72_RS02485	511869..514079	-	2211	WP_037432535.1	replication endonuclease	-
ADP72_RS02490	514185..514409	-	225	WP_037432533.1	TraR/DksA family transcriptional regulator	-
ADP72_RS02495	514409..514645	-	237	WP_053230294.1	DUF2732 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	485328..520704	35376

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T55760 WP_071605322.1 NZ_CP012096:c509710-509456 [Serratia plymuthica]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T55760 NZ_CP012096:c509710-509456 [Serratia plymuthica]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAC
GTGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATACGGATCTGGTTGGATAGCTTA
GGAATTAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12378.92 Da
• Isoelectric Point: 4.4641

>AT55760 WP_037433916.1 NZ_CP012096:c509456-509115 [Serratia plymuthica]
MNNTLKIDGHVAVITFDPEIEMFRGEFVGLNGGADFYAYSVEELKKEGSISLAVFLDECEKDGIAPYKSYSGKVTTRLSP
ERHQALAITAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT55760 NZ_CP012096:c509456-509115 [Serratia plymuthica]
ATGAACAATACACTTAAAATCGACGGCCACGTGGCCGTCATCACATTTGACCCTGAAATTGAAATGTTCCGGGGTGAGTT
TGTCGGACTGAATGGCGGTGCTGACTTCTACGCTTACAGTGTTGAAGAGCTGAAAAAAGAAGGCTCTATTTCACTTGCAG
TCTTTTTAGATGAGTGTGAAAAAGATGGCATTGCGCCGTACAAATCGTATAGCGGCAAAGTGACCACCCGCTTGTCGCCA
GAGCGCCATCAAGCGTTAGCCATTACTGCGCAGGCTACAGGGCAGTCGATTAATGAGCTGCTGAATGAAGGCGTTGATTT
AGTCATTGAGAAACATTCATAA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1