Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3728757..3729286 Replicon chromosome
Accession NZ_CP012095
Organism Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag Mb1595_RS17475 Protein ID WP_003417760.1
Coordinates 3729029..3729286 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag Mb1595_RS17470 Protein ID WP_003417757.1
Coordinates 3728757..3729032 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mb1595_RS22485 3723782..3725086 - 1305 WP_010950875.1 PPE family protein -
Mb1595_RS22490 3725555..3726992 - 1438 Protein_3417 FAD-binding oxidoreductase -
Mb1595_RS17455 3727095..3727484 + 390 WP_010950876.1 DUF732 domain-containing protein -
Mb1595_RS17460 3727498..3727791 - 294 WP_003417749.1 DUF3017 domain-containing protein -
Mb1595_RS17465 3727788..3728633 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
Mb1595_RS17470 3728757..3729032 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
Mb1595_RS17475 3729029..3729286 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
Mb1595_RS17480 3729328..3730518 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
Mb1595_RS17485 3730635..3731003 + 369 WP_003417765.1 FHA domain-containing protein -
Mb1595_RS17490 3731000..3731551 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
Mb1595_RS17495 3731558..3732139 - 582 WP_003417769.1 ATP/GTP-binding protein -
Mb1595_RS17500 3732120..3732488 - 369 WP_003417772.1 DUF742 domain-containing protein -
Mb1595_RS17505 3732466..3732858 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T55749 WP_003417760.1 NZ_CP012095:3729029-3729286 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T55749 NZ_CP012095:3729029-3729286 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT55749 WP_003417757.1 NZ_CP012095:3728757-3729032 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT55749 NZ_CP012095:3728757-3729032 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References