Detailed information of TA system TA055749

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Txe-YefM
• Location: 3728757..3729286
• Replicon: chromosome
• Accession: NZ_CP012095
• Organism: Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TI95
• Locus tag: Mb1595_RS17475
• Protein ID: WP_003417760.1
• Coordinates: 3729029..3729286 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0TI94
• Locus tag: Mb1595_RS17470
• Protein ID: WP_003417757.1
• Coordinates: 3728757..3729032 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Mb1595_RS22485	3723782..3725086	-	1305	WP_010950875.1	PPE family protein	-
Mb1595_RS22490	3725555..3726992	-	1438	Protein_3417	FAD-binding oxidoreductase	-
Mb1595_RS17455	3727095..3727484	+	390	WP_010950876.1	DUF732 domain-containing protein	-
Mb1595_RS17460	3727498..3727791	-	294	WP_003417749.1	DUF3017 domain-containing protein	-
Mb1595_RS17465	3727788..3728633	-	846	WP_010950877.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
Mb1595_RS17470	3728757..3729032	+	276	WP_003417757.1	type II toxin-antitoxin system antitoxin RelJ	Antitoxin
Mb1595_RS17475	3729029..3729286	+	258	WP_003417760.1	Txe/YoeB family addiction module toxin	Toxin
Mb1595_RS17480	3729328..3730518	+	1191	WP_003900033.1	NADH:flavin oxidoreductase	-
Mb1595_RS17485	3730635..3731003	+	369	WP_003417765.1	FHA domain-containing protein	-
Mb1595_RS17490	3731000..3731551	-	552	WP_003417767.1	pentapeptide repeat protein MfpA	-
Mb1595_RS17495	3731558..3732139	-	582	WP_003417769.1	ATP/GTP-binding protein	-
Mb1595_RS17500	3732120..3732488	-	369	WP_003417772.1	DUF742 domain-containing protein	-
Mb1595_RS17505	3732466..3732858	-	393	WP_003417776.1	roadblock/LC7 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10070.30 Da
• Isoelectric Point: 6.4693

>T55749 WP_003417760.1 NZ_CP012095:3729029-3729286 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Nucleotide

• Length: 258 bp

>T55749 NZ_CP012095:3729029-3729286 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10194.35 Da
• Isoelectric Point: 4.6652

>AT55749 WP_003417757.1 NZ_CP012095:3728757-3729032 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Nucleotide

• Length: 276 bp

>AT55749 NZ_CP012095:3728757-3729032 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Structures

Toxin

• PDB: 3OEI

Antitoxin

• AlphaFold DB: G0TI94