Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3667046..3667720 Replicon chromosome
Accession NZ_CP012095
Organism Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag Mb1595_RS17265 Protein ID WP_003417282.1
Coordinates 3667046..3667474 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag Mb1595_RS17270 Protein ID WP_003417286.1
Coordinates 3667478..3667720 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mb1595_RS17240 3662868..3663269 - 402 WP_003417264.1 cytidine deaminase -
Mb1595_RS17245 3663410..3663844 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
Mb1595_RS17250 3663841..3664275 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
Mb1595_RS17255 3664404..3666176 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
Mb1595_RS17260 3666176..3666967 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
Mb1595_RS17265 3667046..3667474 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
Mb1595_RS17270 3667478..3667720 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
Mb1595_RS17275 3667842..3668456 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
Mb1595_RS17280 3668453..3669118 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
Mb1595_RS17285 3669119..3669652 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
Mb1595_RS17290 3669649..3670023 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
Mb1595_RS17295 3670120..3671184 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T55748 WP_003417282.1 NZ_CP012095:c3667474-3667046 [Mycobacterium tuberculosis variant bovis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T55748 NZ_CP012095:c3667474-3667046 [Mycobacterium tuberculosis variant bovis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT55748 WP_003417286.1 NZ_CP012095:c3667720-3667478 [Mycobacterium tuberculosis variant bovis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT55748 NZ_CP012095:c3667720-3667478 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References