Detailed information of TA system TA055735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2826164..2826804
• Replicon: chromosome
• Accession: NZ_CP012095
• Organism: Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: Mb1595_RS13225
• Protein ID: WP_003412970.1
• Coordinates: 2826164..2826583 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: Mb1595_RS13230
• Protein ID: WP_003412975.1
• Coordinates: 2826580..2826804 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Mb1595_RS13200	2821749..2822471	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
Mb1595_RS13205	2822988..2823215	+	228	WP_003412960.1	type II toxin-antitoxin system VapB family antitoxin	-
Mb1595_RS13210	2823212..2823613	+	402	WP_003412963.1	PIN domain-containing protein	-
Mb1595_RS13215	2823648..2824568	-	921	WP_003412965.1	restriction endonuclease	-
Mb1595_RS22095	2824909..2825154	-	246	WP_162146607.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
Mb1595_RS13220	2825213..2826163	+	951	WP_003911916.1	Lsr2 family protein	-
Mb1595_RS13225	2826164..2826583	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
Mb1595_RS13230	2826580..2826804	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
Mb1595_RS13235	2826835..2829678	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
Mb1595_RS13240	2829750..2830151	-	402	WP_003412981.1	hypothetical protein	-
Mb1595_RS13245	2830151..2830621	-	471	WP_003412985.1	transcription antitermination factor NusB	-
Mb1595_RS13250	2830624..2831187	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T55735 WP_003412970.1 NZ_CP012095:c2826583-2826164 [Mycobacterium tuberculosis variant bovis]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T55735 NZ_CP012095:c2826583-2826164 [Mycobacterium tuberculosis variant bovis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT55735 WP_003412975.1 NZ_CP012095:c2826804-2826580 [Mycobacterium tuberculosis variant bovis]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT55735 NZ_CP012095:c2826804-2826580 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09