Detailed information of TA system TA055733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2387763..2388292
• Replicon: chromosome
• Accession: NZ_CP012095
• Organism: Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: Mb1595_RS11170
• Protein ID: WP_003411124.1
• Coordinates: 2387763..2388080 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: Mb1595_RS11175
• Protein ID: WP_003411127.1
• Coordinates: 2388077..2388292 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Mb1595_RS11140	2382784..2383860	+	1077	WP_003411110.1	hypothetical protein	-
Mb1595_RS11145	2383857..2384138	+	282	WP_003411112.1	hypothetical protein	-
Mb1595_RS11150	2384174..2385247	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
Mb1595_RS11155	2385252..2385782	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
Mb1595_RS11160	2385830..2387176	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
Mb1595_RS11170	2387763..2388080	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Mb1595_RS11175	2388077..2388292	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
Mb1595_RS11180	2388547..2389605	+	1059	WP_003411129.1	hypothetical protein	-
Mb1595_RS11185	2389735..2390091	-	357	WP_003411130.1	hypothetical protein	-
Mb1595_RS11190	2390186..2390968	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
Mb1595_RS11195	2391236..2391526	-	291	WP_003900476.1	YggT family protein	-
Mb1595_RS11200	2391688..2392344	-	657	WP_003411133.1	cell division protein SepF	-
Mb1595_RS11205	2392410..2393186	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T55733 WP_003411124.1 NZ_CP012095:c2388080-2387763 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T55733 NZ_CP012095:c2388080-2387763 [Mycobacterium tuberculosis variant bovis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT55733 WP_003411127.1 NZ_CP012095:c2388292-2388077 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT55733 NZ_CP012095:c2388292-2388077 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4