Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2387763..2388292 Replicon chromosome
Accession NZ_CP012095
Organism Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag Mb1595_RS11170 Protein ID WP_003411124.1
Coordinates 2387763..2388080 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag Mb1595_RS11175 Protein ID WP_003411127.1
Coordinates 2388077..2388292 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mb1595_RS11140 2382784..2383860 + 1077 WP_003411110.1 hypothetical protein -
Mb1595_RS11145 2383857..2384138 + 282 WP_003411112.1 hypothetical protein -
Mb1595_RS11150 2384174..2385247 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
Mb1595_RS11155 2385252..2385782 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
Mb1595_RS11160 2385830..2387176 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
Mb1595_RS11170 2387763..2388080 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Mb1595_RS11175 2388077..2388292 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
Mb1595_RS11180 2388547..2389605 + 1059 WP_003411129.1 hypothetical protein -
Mb1595_RS11185 2389735..2390091 - 357 WP_003411130.1 hypothetical protein -
Mb1595_RS11190 2390186..2390968 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
Mb1595_RS11195 2391236..2391526 - 291 WP_003900476.1 YggT family protein -
Mb1595_RS11200 2391688..2392344 - 657 WP_003411133.1 cell division protein SepF -
Mb1595_RS11205 2392410..2393186 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T55733 WP_003411124.1 NZ_CP012095:c2388080-2387763 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T55733 NZ_CP012095:c2388080-2387763 [Mycobacterium tuberculosis variant bovis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT55733 WP_003411127.1 NZ_CP012095:c2388292-2388077 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT55733 NZ_CP012095:c2388292-2388077 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References