Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2216620..2217518 Replicon chromosome
Accession NZ_CP012095
Organism Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag Mb1595_RS10355 Protein ID WP_003410001.1
Coordinates 2216620..2217180 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag Mb1595_RS10360 Protein ID WP_003410003.1
Coordinates 2217177..2217518 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mb1595_RS10325 2211789..2212442 - 654 WP_003409976.1 cutinase Cfp21 -
Mb1595_RS10330 2212557..2212787 + 231 WP_003409980.1 DUF167 domain-containing protein -
Mb1595_RS10335 2212872..2213783 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
Mb1595_RS10340 2213892..2214491 + 600 WP_003409989.1 L-lysine exporter -
Mb1595_RS10345 2214907..2215335 + 429 WP_003409992.1 cellulose-binding protein -
Mb1595_RS10350 2215561..2216100 + 540 WP_031702531.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
Mb1595_RS10355 2216620..2217180 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
Mb1595_RS10360 2217177..2217518 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
Mb1595_RS10365 2217604..2217861 + 258 WP_003410006.1 hypothetical protein -
Mb1595_RS10370 2217762..2218097 - 336 WP_003410009.1 dehydrogenase -
Mb1595_RS10375 2218186..2218530 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
Mb1595_RS10380 2218524..2218772 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
Mb1595_RS10385 2218872..2221187 - 2316 WP_003899120.1 cation transporter ATPase CptG -
Mb1595_RS10390 2221184..2221456 - 273 WP_003410017.1 DUF1490 family protein -
Mb1595_RS10395 2221509..2221865 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T55727 WP_003410001.1 NZ_CP012095:c2217180-2216620 [Mycobacterium tuberculosis variant bovis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T55727 NZ_CP012095:c2217180-2216620 [Mycobacterium tuberculosis variant bovis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT55727 WP_003410003.1 NZ_CP012095:c2217518-2217177 [Mycobacterium tuberculosis variant bovis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT55727 NZ_CP012095:c2217518-2217177 [Mycobacterium tuberculosis variant bovis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References