Detailed information of TA system TA055726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2209294..2209982
• Replicon: chromosome
• Accession: NZ_CP012095
• Organism: Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P0A653
• Locus tag: Mb1595_RS10310
• Protein ID: WP_003409958.1
• Coordinates: 2209294..2209713 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ28
• Locus tag: Mb1595_RS10315
• Protein ID: WP_003409968.1
• Coordinates: 2209722..2209982 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Mb1595_RS10285	2204300..2204605	+	306	Protein_2011	ABC transporter permease	-
Mb1595_RS10290	2204789..2205637	+	849	WP_010950638.1	class I SAM-dependent methyltransferase	-
Mb1595_RS10295	2205600..2207045	-	1446	WP_003409946.1	APC family permease	-
Mb1595_RS10300	2207224..2207910	-	687	WP_003409954.1	immunoprotective protein Mpt64	-
Mb1595_RS10305	2208101..2209069	-	969	WP_003409956.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
Mb1595_RS10310	2209294..2209713	-	420	WP_003409958.1	type II toxin-antitoxin system VapC family toxin	Toxin
Mb1595_RS10315	2209722..2209982	-	261	WP_003409968.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
Mb1595_RS10320	2210125..2211801	+	1677	WP_010950639.1	PecA family PE domain-processing aspartic protease	-
Mb1595_RS10325	2211789..2212442	-	654	WP_003409976.1	cutinase Cfp21	-
Mb1595_RS10330	2212557..2212787	+	231	WP_003409980.1	DUF167 domain-containing protein	-
Mb1595_RS10335	2212872..2213783	-	912	WP_003409986.1	ArgP/LysG family DNA-binding transcriptional regulator	-
Mb1595_RS10340	2213892..2214491	+	600	WP_003409989.1	L-lysine exporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (2-81)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14724.89 Da
• Isoelectric Point: 7.9535

>T55726 WP_003409958.1 NZ_CP012095:c2209713-2209294 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Nucleotide

• Length: 420 bp

>T55726 NZ_CP012095:c2209713-2209294 [Mycobacterium tuberculosis variant bovis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9528.88 Da
• Isoelectric Point: 5.1007

>AT55726 WP_003409968.1 NZ_CP012095:c2209982-2209722 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Nucleotide

• Length: 261 bp

>AT55726 NZ_CP012095:c2209982-2209722 [Mycobacterium tuberculosis variant bovis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Structures

Toxin

• AlphaFold DB: A0A829C4H9

Antitoxin

• AlphaFold DB: A0A829C483