Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2200280..2200824 Replicon chromosome
Accession NZ_CP012095
Organism Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag Mb1595_RS10250 Protein ID WP_003409896.1
Coordinates 2200280..2200576 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag Mb1595_RS10255 Protein ID WP_003409899.1
Coordinates 2200573..2200824 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mb1595_RS10195 2195313..2195663 - 351 WP_003409871.1 hypothetical protein -
Mb1595_RS10200 2195674..2196576 - 903 WP_003409874.1 hypothetical protein -
Mb1595_RS10205 2196597..2196788 - 192 WP_003409876.1 hypothetical protein -
Mb1595_RS10210 2196789..2197085 - 297 WP_003409877.1 hypothetical protein -
Mb1595_RS10215 2197325..2197540 + 216 WP_003409878.1 antitoxin -
Mb1595_RS10220 2197537..2197848 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
Mb1595_RS22060 2197822..2198343 - 522 WP_010950637.1 hypothetical protein -
Mb1595_RS10230 2198318..2198695 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
Mb1595_RS10235 2198737..2199186 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
Mb1595_RS10240 2199183..2199728 + 546 WP_003409891.1 SecB-like chaperone -
Mb1595_RS10245 2199617..2200231 - 615 WP_003901296.1 hypothetical protein -
Mb1595_RS10250 2200280..2200576 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Mb1595_RS10255 2200573..2200824 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
Mb1595_RS10260 2200811..2201305 + 495 WP_003899099.1 hypothetical protein -
Mb1595_RS10265 2201465..2201872 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
Mb1595_RS10270 2201876..2202148 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
Mb1595_RS10275 2202181..2203401 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
Mb1595_RS10285 2204300..2204605 + 306 Protein_2011 ABC transporter permease -
Mb1595_RS10290 2204789..2205637 + 849 WP_010950638.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T55725 WP_003409896.1 NZ_CP012095:c2200576-2200280 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T55725 NZ_CP012095:c2200576-2200280 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT55725 WP_003409899.1 NZ_CP012095:c2200824-2200573 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT55725 NZ_CP012095:c2200824-2200573 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References