Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1957636..1958096 Replicon chromosome
Accession NZ_CP012095
Organism Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag Mb1595_RS09140 Protein ID WP_003408531.1
Coordinates 1957848..1958096 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag Mb1595_RS09135 Protein ID WP_003408528.1
Coordinates 1957636..1957848 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mb1595_RS09120 1954114..1955301 - 1188 WP_043856388.1 nitrate transporter NarK -
Mb1595_RS09125 1955588..1955872 + 285 WP_003408522.1 DUF1876 domain-containing protein -
Mb1595_RS09130 1955886..1957568 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
Mb1595_RS09135 1957636..1957848 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
Mb1595_RS09140 1957848..1958096 + 249 WP_003408531.1 hypothetical protein Toxin
Mb1595_RS09145 1958104..1958842 + 739 Protein_1783 hypothetical protein -
Mb1595_RS09150 1958936..1960636 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
Mb1595_RS09155 1960921..1961322 - 402 WP_010950586.1 hypothetical protein -
Mb1595_RS09160 1961393..1961923 - 531 WP_011799212.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T55722 WP_003408531.1 NZ_CP012095:1957848-1958096 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T55722 NZ_CP012095:1957848-1958096 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT55722 WP_003408528.1 NZ_CP012095:1957636-1957848 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT55722 NZ_CP012095:1957636-1957848 [Mycobacterium tuberculosis variant bovis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References