Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 704381..705024 Replicon chromosome
Accession NZ_CP012095
Organism Mycobacterium tuberculosis variant bovis strain 1595

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag Mb1595_RS03180 Protein ID WP_003403187.1
Coordinates 704623..705024 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag Mb1595_RS03175 Protein ID WP_003403184.1
Coordinates 704381..704626 (+) Length 82 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mb1595_RS03140 699661..700191 - 531 WP_003917320.1 two component system sensor kinase HK2 -
Mb1595_RS03145 700175..700870 - 696 WP_197044064.1 response regulator transcription factor -
Mb1595_RS03150 700993..701304 + 312 WP_003403164.1 hypothetical protein -
Mb1595_RS03155 701376..702326 + 951 WP_003907436.1 DUF1259 domain-containing protein -
Mb1595_RS03160 702567..703151 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
Mb1595_RS03165 703153..703866 + 714 Protein_626 IS607 family element transposase accessory protein TnpB -
Mb1595_RS03170 703866..704336 + 471 WP_003898523.1 hypothetical protein -
Mb1595_RS03175 704381..704626 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
Mb1595_RS03180 704623..705024 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
Mb1595_RS21635 705412..705579 - 168 WP_077385191.1 DUF3800 domain-containing protein -
Mb1595_RS21640 705612..705809 - 198 WP_003403191.1 hypothetical protein -
Mb1595_RS03195 705889..707046 - 1158 WP_003403193.1 hypothetical protein -
Mb1595_RS03200 707098..707319 - 222 WP_003898525.1 DUF4926 domain-containing protein -
Mb1595_RS03205 707461..708066 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-124)

Antitoxin

(1-80)


Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T55701 WP_003403187.1 NZ_CP012095:704623-705024 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T55701 NZ_CP012095:704623-705024 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT55701 WP_003403184.1 NZ_CP012095:704381-704626 [Mycobacterium tuberculosis variant bovis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT55701 NZ_CP012095:704381-704626 [Mycobacterium tuberculosis variant bovis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6


Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References