55690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3773523..3774052 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag TBPG_RS17720 Protein ID WP_003417760.1
Coordinates 3773795..3774052 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag TBPG_RS17715 Protein ID WP_003417757.1
Coordinates 3773523..3773798 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS22635 3770321..3771758 - 1438 Protein_3463 FAD-binding oxidoreductase -
TBPG_RS17700 3771861..3772250 + 390 WP_003417745.1 DUF732 domain-containing protein -
TBPG_RS17705 3772264..3772557 - 294 WP_003417749.1 DUF3017 domain-containing protein -
TBPG_RS17710 3772554..3773399 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
TBPG_RS17715 3773523..3773798 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
TBPG_RS17720 3773795..3774052 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
TBPG_RS17725 3774094..3775284 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
TBPG_RS17730 3775401..3775769 + 369 WP_003417765.1 FHA domain-containing protein -
TBPG_RS17735 3775766..3776317 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
TBPG_RS17740 3776324..3776905 - 582 WP_003417769.1 ATP/GTP-binding protein -
TBPG_RS17745 3776886..3777254 - 369 WP_003417772.1 DUF742 domain-containing protein -
TBPG_RS17750 3777232..3777624 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T55690 WP_003417760.1 NZ_CP012090:3773795-3774052 [Mycobacterium tuberculosis W-148]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T55690 NZ_CP012090:3773795-3774052 [Mycobacterium tuberculosis W-148]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT55690 WP_003417757.1 NZ_CP012090:3773523-3773798 [Mycobacterium tuberculosis W-148]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT55690 NZ_CP012090:3773523-3773798 [Mycobacterium tuberculosis W-148]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References