55689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3702899..3703524 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag TBPG_RS17505 Protein ID WP_003403218.1
Coordinates 3702899..3703300 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag TBPG_RS17510 Protein ID WP_003403213.1
Coordinates 3703297..3703524 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS17480 3697989..3698936 - 948 WP_003403232.1 DUF732 domain-containing protein -
TBPG_RS17485 3699040..3700104 - 1065 WP_003898532.1 hypothetical protein -
TBPG_RS17495 3700499..3701590 - 1092 WP_003900977.1 galactokinase -
TBPG_RS21745 3701587..3702078 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
TBPG_RS21750 3702075..3702770 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
TBPG_RS17505 3702899..3703300 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
TBPG_RS17510 3703297..3703524 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
TBPG_RS17520 3703719..3703961 - 243 WP_003403210.1 hypothetical protein -
TBPG_RS17525 3703958..3704708 - 751 Protein_3431 hypothetical protein -
TBPG_RS17530 3704792..3707359 + 2568 WP_003901879.1 SEC-C domain-containing protein -
TBPG_RS17535 3707378..3707983 - 606 WP_003898526.1 hypothetical protein -
TBPG_RS17540 3708125..3708346 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T55689 WP_003403218.1 NZ_CP012090:c3703300-3702899 [Mycobacterium tuberculosis W-148]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T55689 NZ_CP012090:c3703300-3702899 [Mycobacterium tuberculosis W-148]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT55689 WP_003403213.1 NZ_CP012090:c3703524-3703297 [Mycobacterium tuberculosis W-148]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT55689 NZ_CP012090:c3703524-3703297 [Mycobacterium tuberculosis W-148]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References