55688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3697247..3697896 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag TBPG_RS17470 Protein ID WP_003403236.1
Coordinates 3697247..3697642 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag TBPG_RS17475 Protein ID WP_003403235.1
Coordinates 3697642..3697896 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS17445 3692574..3694301 + 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -
TBPG_RS17450 3694394..3695545 + 1152 WP_003403248.1 FIST C-terminal domain-containing protein -
TBPG_RS17455 3695617..3696024 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
TBPG_RS17460 3696021..3696281 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TBPG_RS17465 3696413..3697153 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
TBPG_RS17470 3697247..3697642 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
TBPG_RS17475 3697642..3697896 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
TBPG_RS17480 3697989..3698936 - 948 WP_003403232.1 DUF732 domain-containing protein -
TBPG_RS17485 3699040..3700104 - 1065 WP_003898532.1 hypothetical protein -
TBPG_RS17495 3700499..3701590 - 1092 WP_003900977.1 galactokinase -
TBPG_RS21745 3701587..3702078 - 492 WP_003905354.1 galactose-1-phosphate uridylyltransferase -
TBPG_RS21750 3702075..3702770 - 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T55688 WP_003403236.1 NZ_CP012090:c3697642-3697247 [Mycobacterium tuberculosis W-148]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T55688 NZ_CP012090:c3697642-3697247 [Mycobacterium tuberculosis W-148]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT55688 WP_003403235.1 NZ_CP012090:c3697896-3697642 [Mycobacterium tuberculosis W-148]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT55688 NZ_CP012090:c3697896-3697642 [Mycobacterium tuberculosis W-148]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References