55686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3660156..3660789 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag TBPG_RS17285 Protein ID WP_003403365.1
Coordinates 3660406..3660789 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag TBPG_RS17280 Protein ID WP_003403368.1
Coordinates 3660156..3660311 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS17250 3655273..3657636 - 2364 WP_003901895.1 arylsulfatase AtsD -
TBPG_RS17255 3657750..3658004 + 255 WP_003911263.1 antitoxin VapB7 -
TBPG_RS17260 3658001..3658438 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
TBPG_RS17265 3658548..3658793 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
TBPG_RS17270 3658780..3659088 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
TBPG_RS17275 3659364..3660080 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
TBPG_RS17280 3660156..3660311 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBPG_RS17285 3660406..3660789 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
TBPG_RS17290 3661177..3662187 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
TBPG_RS17295 3662268..3663773 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
TBPG_RS17300 3663844..3664539 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
TBPG_RS17305 3664532..3664924 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
TBPG_RS17310 3664961..3665497 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T55686 WP_003403365.1 NZ_CP012090:3660406-3660789 [Mycobacterium tuberculosis W-148]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T55686 NZ_CP012090:3660406-3660789 [Mycobacterium tuberculosis W-148]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT55686 WP_003403368.1 NZ_CP012090:3660156-3660311 [Mycobacterium tuberculosis W-148]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT55686 NZ_CP012090:3660156-3660311 [Mycobacterium tuberculosis W-148]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References