Detailed information of TA system TA055684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-mazE/PIN(toxin)
• Location: 3658001..3658793
• Replicon: chromosome
• Accession: NZ_CP012090
• Organism: Mycobacterium tuberculosis W-148

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WFB2
• Locus tag: TBPG_RS17260
• Protein ID: WP_003403386.1
• Coordinates: 3658001..3658438 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TQE0
• Locus tag: TBPG_RS17265
• Protein ID: WP_003403381.1
• Coordinates: 3658548..3658793 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBPG_RS17235	3654464..3654637	-	174	WP_003898549.1	hypothetical protein	-
TBPG_RS17240	3654634..3654972	-	339	WP_003403405.1	PIN domain-containing protein	-
TBPG_RS17245	3654884..3655210	-	327	WP_003403401.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
TBPG_RS17250	3655273..3657636	-	2364	WP_003901895.1	arylsulfatase AtsD	-
TBPG_RS17255	3657750..3658004	+	255	WP_003911263.1	antitoxin VapB7	-
TBPG_RS17260	3658001..3658438	+	438	WP_003403386.1	type II toxin-antitoxin system VapC family toxin	Toxin
TBPG_RS17265	3658548..3658793	+	246	WP_003403381.1	ribbon-helix-helix protein, CopG family	Antitoxin
TBPG_RS17270	3658780..3659088	+	309	WP_003403376.1	type II toxin-antitoxin system PemK/MazF family toxin	-
TBPG_RS17275	3659364..3660080	+	717	WP_003403371.1	CPBP family intramembrane metalloprotease	-
TBPG_RS17280	3660156..3660311	+	156	WP_003403368.1	type II toxin-antitoxin system VapB family antitoxin	-
TBPG_RS17285	3660406..3660789	+	384	WP_003403365.1	ribonuclease VapC6	-
TBPG_RS17290	3661177..3662187	-	1011	WP_003911248.1	ABC transporter ATP-binding protein	-
TBPG_RS17295	3662268..3663773	-	1506	WP_003403360.1	carotenoid cleavage oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15245.39 Da
• Isoelectric Point: 5.1865

>T55684 WP_003403386.1 NZ_CP012090:3658001-3658438 [Mycobacterium tuberculosis W-148]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Nucleotide

• Length: 438 bp

>T55684 NZ_CP012090:3658001-3658438 [Mycobacterium tuberculosis W-148]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9169.01 Da
• Isoelectric Point: 4.2070

>AT55684 WP_003403381.1 NZ_CP012090:3658548-3658793 [Mycobacterium tuberculosis W-148]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Nucleotide

• Length: 246 bp

>AT55684 NZ_CP012090:3658548-3658793 [Mycobacterium tuberculosis W-148]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BSW5

Antitoxin

• AlphaFold DB: G0TQE0