55673

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2884840..2885410 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag TBPG_RS13555 Protein ID WP_003414166.1
Coordinates 2884840..2885196 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag TBPG_RS13560 Protein ID WP_003901465.1
Coordinates 2885180..2885410 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS13535 2880292..2881980 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
TBPG_RS13540 2881984..2882310 - 327 WP_003414157.1 hypothetical protein -
TBPG_RS13545 2882483..2883070 + 588 WP_003914429.1 DUF3558 family protein -
TBPG_RS13550 2883089..2884738 + 1650 Protein_2663 CocE/NonD family hydrolase -
TBPG_RS13555 2884840..2885196 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
TBPG_RS13560 2885180..2885410 - 231 WP_003901465.1 antitoxin MazE Antitoxin
TBPG_RS13565 2885453..2886496 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
TBPG_RS22205 2886687..2886962 + 276 WP_003911993.1 DUF1778 domain-containing protein -
TBPG_RS22570 2887138..2887392 - 255 WP_003917684.1 hypothetical protein -
TBPG_RS13580 2887540..2887944 + 405 WP_003414181.1 hypothetical protein -
TBPG_RS13585 2887941..2888132 + 192 WP_003414184.1 hypothetical protein -
TBPG_RS13590 2888196..2889485 + 1290 Protein_2671 transposase family protein -
TBPG_RS13595 2889719..2889976 + 258 WP_003899489.1 hypothetical protein -
TBPG_RS13600 2890081..2890392 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T55673 WP_003414166.1 NZ_CP012090:c2885196-2884840 [Mycobacterium tuberculosis W-148]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T55673 NZ_CP012090:c2885196-2884840 [Mycobacterium tuberculosis W-148]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT55673 WP_003901465.1 NZ_CP012090:c2885410-2885180 [Mycobacterium tuberculosis W-148]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT55673 NZ_CP012090:c2885410-2885180 [Mycobacterium tuberculosis W-148]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References