Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2704493..2705207 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag TBPG_RS12530 Protein ID WP_003413460.1
Coordinates 2704767..2705207 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag TBPG_RS12525 Protein ID WP_003413456.1
Coordinates 2704493..2704780 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS12490 2699915..2700160 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
TBPG_RS12495 2700157..2700561 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
TBPG_RS12500 2700778..2701398 + 621 WP_003413441.1 DUF4178 domain-containing protein -
TBPG_RS12505 2701409..2701903 + 495 WP_003413444.1 DUF2617 family protein -
TBPG_RS12510 2701900..2702331 + 432 WP_003899390.1 DUF4247 domain-containing protein -
TBPG_RS12515 2702356..2702814 + 459 WP_003413451.1 DUF350 domain-containing protein -
TBPG_RS12520 2702811..2704382 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
TBPG_RS12525 2704493..2704780 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
TBPG_RS12530 2704767..2705207 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
TBPG_RS12535 2705228..2705983 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
TBPG_RS12540 2706116..2706712 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
TBPG_RS12545 2706720..2707565 - 846 WP_003413466.1 acyl-CoA thioesterase II -
TBPG_RS12550 2707594..2708493 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
TBPG_RS12555 2708621..2709295 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T55669 WP_003413460.1 NZ_CP012090:2704767-2705207 [Mycobacterium tuberculosis W-148]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T55669 NZ_CP012090:2704767-2705207 [Mycobacterium tuberculosis W-148]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT55669 WP_003413456.1 NZ_CP012090:2704493-2704780 [Mycobacterium tuberculosis W-148]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT55669 NZ_CP012090:2704493-2704780 [Mycobacterium tuberculosis W-148]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References