55668

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2644151..2644788 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag TBPG_RS12265 Protein ID WP_003413180.1
Coordinates 2644151..2644546 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag TBPG_RS12270 Protein ID WP_003413183.1
Coordinates 2644543..2644788 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS12230 2639555..2640766 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
TBPG_RS12235 2640893..2641552 + 660 WP_003902296.1 hypothetical protein -
TBPG_RS12240 2641549..2642211 + 663 WP_003905878.1 hypothetical protein -
TBPG_RS22190 2642208..2642485 + 278 Protein_2401 type II toxin-antitoxin system VapB family antitoxin -
TBPG_RS12245 2642578..2642991 + 414 WP_003413164.1 PIN domain nuclease -
TBPG_RS12250 2643030..2643287 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
TBPG_RS12255 2643284..2643661 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
TBPG_RS12260 2643677..2644051 - 375 WP_003413177.1 hypothetical protein -
TBPG_RS12265 2644151..2644546 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
TBPG_RS12270 2644543..2644788 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
TBPG_RS12275 2645199..2645618 - 420 WP_003413190.1 A24 family peptidase -
TBPG_RS12280 2645630..2646439 - 810 WP_003413193.1 shikimate dehydrogenase -
TBPG_RS12285 2646436..2647689 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
TBPG_RS12290 2647682..2648194 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T55668 WP_003413180.1 NZ_CP012090:c2644546-2644151 [Mycobacterium tuberculosis W-148]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T55668 NZ_CP012090:c2644546-2644151 [Mycobacterium tuberculosis W-148]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT55668 WP_003413183.1 NZ_CP012090:c2644788-2644543 [Mycobacterium tuberculosis W-148]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT55668 NZ_CP012090:c2644788-2644543 [Mycobacterium tuberculosis W-148]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References