55666

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2642578..2643287 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag TBPG_RS12245 Protein ID WP_003413164.1
Coordinates 2642578..2642991 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag TBPG_RS12250 Protein ID WP_003413167.1
Coordinates 2643030..2643287 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS12220 2637632..2638837 - 1206 WP_003413027.1 chorismate synthase -
TBPG_RS12225 2638945..2639259 + 315 WP_009937839.1 hypothetical protein -
TBPG_RS12230 2639555..2640766 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
TBPG_RS12235 2640893..2641552 + 660 WP_003902296.1 hypothetical protein -
TBPG_RS12240 2641549..2642211 + 663 WP_003905878.1 hypothetical protein -
TBPG_RS22190 2642208..2642485 + 278 Protein_2401 type II toxin-antitoxin system VapB family antitoxin -
TBPG_RS12245 2642578..2642991 + 414 WP_003413164.1 PIN domain nuclease Toxin
TBPG_RS12250 2643030..2643287 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
TBPG_RS12255 2643284..2643661 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
TBPG_RS12260 2643677..2644051 - 375 WP_003413177.1 hypothetical protein -
TBPG_RS12265 2644151..2644546 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
TBPG_RS12270 2644543..2644788 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
TBPG_RS12275 2645199..2645618 - 420 WP_003413190.1 A24 family peptidase -
TBPG_RS12280 2645630..2646439 - 810 WP_003413193.1 shikimate dehydrogenase -
TBPG_RS12285 2646436..2647689 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
TBPG_RS12290 2647682..2648194 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T55666 WP_003413164.1 NZ_CP012090:2642578-2642991 [Mycobacterium tuberculosis W-148]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T55666 NZ_CP012090:2642578-2642991 [Mycobacterium tuberculosis W-148]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT55666 WP_003413167.1 NZ_CP012090:2643030-2643287 [Mycobacterium tuberculosis W-148]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT55666 NZ_CP012090:2643030-2643287 [Mycobacterium tuberculosis W-148]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References