Detailed information of TA system TA055665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2628692..2629332
• Replicon: chromosome
• Accession: NZ_CP012090
• Organism: Mycobacterium tuberculosis W-148

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: TBPG_RS12165
• Protein ID: WP_003412970.1
• Coordinates: 2628692..2629111 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: TBPG_RS12170
• Protein ID: WP_003412975.1
• Coordinates: 2629108..2629332 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBPG_RS12140	2624282..2625004	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
TBPG_RS12145	2625521..2625743	+	223	Protein_2380	type II toxin-antitoxin system VapB family antitoxin	-
TBPG_RS12150	2625740..2626141	+	402	WP_003412963.1	PIN domain-containing protein	-
TBPG_RS12155	2626176..2627096	-	921	WP_003412965.1	restriction endonuclease	-
TBPG_RS22545	2627437..2627682	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
TBPG_RS12160	2627741..2628691	+	951	WP_003911916.1	Lsr2 family protein	-
TBPG_RS12165	2628692..2629111	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
TBPG_RS12170	2629108..2629332	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
TBPG_RS12175	2629363..2632206	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
TBPG_RS12180	2632278..2632679	-	402	WP_003412981.1	hypothetical protein	-
TBPG_RS12185	2632679..2633149	-	471	WP_003899364.1	transcription antitermination factor NusB	-
TBPG_RS12190	2633152..2633715	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T55665 WP_003412970.1 NZ_CP012090:c2629111-2628692 [Mycobacterium tuberculosis W-148]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T55665 NZ_CP012090:c2629111-2628692 [Mycobacterium tuberculosis W-148]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT55665 WP_003412975.1 NZ_CP012090:c2629332-2629108 [Mycobacterium tuberculosis W-148]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT55665 NZ_CP012090:c2629332-2629108 [Mycobacterium tuberculosis W-148]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09