55659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2027831..2028457 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag TBPG_RS09335 Protein ID WP_003410075.1
Coordinates 2028059..2028457 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag TBPG_RS09330 Protein ID WP_003911750.1
Coordinates 2027831..2028058 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS09320 2025870..2026214 - 345 WP_003410065.1 ferredoxin family protein -
TBPG_RS09325 2026403..2027572 - 1170 WP_003899126.1 ATP-binding protein -
TBPG_RS09330 2027831..2028058 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBPG_RS09335 2028059..2028457 + 399 WP_003410075.1 PIN domain nuclease Toxin
TBPG_RS09340 2028640..2029071 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
TBPG_RS09345 2029172..2029606 + 435 WP_003914358.1 DUF1398 domain-containing protein -
TBPG_RS21190 2030043..2030222 - 180 Protein_1843 hypothetical protein -
TBPG_RS09350 2030283..2030930 + 648 WP_071854215.1 transposase -
TBPG_RS09355 2030884..2031474 + 591 WP_003899131.1 IS110 family transposase -
TBPG_RS09360 2031602..2032858 - 1257 WP_003902247.1 HNH endonuclease -
TBPG_RS09365 2033212..2033412 + 201 Protein_1847 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T55659 WP_003410075.1 NZ_CP012090:2028059-2028457 [Mycobacterium tuberculosis W-148]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T55659 NZ_CP012090:2028059-2028457 [Mycobacterium tuberculosis W-148]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT55659 WP_003911750.1 NZ_CP012090:2027831-2028058 [Mycobacterium tuberculosis W-148]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT55659 NZ_CP012090:2027831-2028058 [Mycobacterium tuberculosis W-148]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References