55656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1995201..1995889 Replicon chromosome
Accession NZ_CP012090
Organism Mycobacterium tuberculosis W-148

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag TBPG_RS09170 Protein ID WP_003409958.1
Coordinates 1995201..1995620 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag TBPG_RS09175 Protein ID WP_003409968.1
Coordinates 1995629..1995889 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBPG_RS21165 1991056..1991268 - 213 Protein_1801 class I SAM-dependent methyltransferase -
TBPG_RS21170 1991272..1991544 + 273 Protein_1802 SAM-dependent methyltransferase -
TBPG_RS09155 1991507..1992952 - 1446 WP_003899115.1 APC family permease -
TBPG_RS09160 1993131..1993817 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
TBPG_RS09165 1994008..1994976 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
TBPG_RS09170 1995201..1995620 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
TBPG_RS09175 1995629..1995889 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBPG_RS09180 1996032..1997708 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
TBPG_RS09185 1997696..1998349 - 654 WP_003409976.1 cutinase Cfp21 -
TBPG_RS09190 1998464..1998694 + 231 WP_003409980.1 DUF167 domain-containing protein -
TBPG_RS09195 1998779..1999690 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
TBPG_RS09200 1999799..2000398 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T55656 WP_003409958.1 NZ_CP012090:c1995620-1995201 [Mycobacterium tuberculosis W-148]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T55656 NZ_CP012090:c1995620-1995201 [Mycobacterium tuberculosis W-148]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT55656 WP_003409968.1 NZ_CP012090:c1995889-1995629 [Mycobacterium tuberculosis W-148]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT55656 NZ_CP012090:c1995889-1995629 [Mycobacterium tuberculosis W-148]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References