Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1970729..1971273 | Replicon | chromosome |
| Accession | NZ_CP012090 | ||
| Organism | Mycobacterium tuberculosis W-148 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | TBPG_RS09025 | Protein ID | WP_003409896.1 |
| Coordinates | 1970729..1971025 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | TBPG_RS09030 | Protein ID | WP_003409899.1 |
| Coordinates | 1971022..1971273 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| TBPG_RS08970 | 1965762..1966112 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| TBPG_RS08975 | 1966123..1967025 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| TBPG_RS08980 | 1967046..1967237 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| TBPG_RS08985 | 1967238..1967534 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| TBPG_RS08990 | 1967774..1967989 | + | 216 | WP_003409878.1 | antitoxin | - |
| TBPG_RS08995 | 1967986..1968297 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| TBPG_RS22500 | 1968271..1968792 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| TBPG_RS09005 | 1968767..1969144 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| TBPG_RS09010 | 1969186..1969635 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| TBPG_RS09015 | 1969632..1970177 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| TBPG_RS09020 | 1970066..1970680 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| TBPG_RS09025 | 1970729..1971025 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| TBPG_RS09030 | 1971022..1971273 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| TBPG_RS09035 | 1971260..1971754 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| TBPG_RS09040 | 1971914..1972321 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| TBPG_RS09045 | 1972325..1972597 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| TBPG_RS09050 | 1972630..1973850 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| TBPG_RS09060 | 1974749..1975546 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T55655 WP_003409896.1 NZ_CP012090:c1971025-1970729 [Mycobacterium tuberculosis W-148]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T55655 NZ_CP012090:c1971025-1970729 [Mycobacterium tuberculosis W-148]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT55655 WP_003409899.1 NZ_CP012090:c1971273-1971022 [Mycobacterium tuberculosis W-148]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT55655 NZ_CP012090:c1971273-1971022 [Mycobacterium tuberculosis W-148]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |