Detailed information of TA system TA055642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 701550..702193
• Replicon: chromosome
• Accession: NZ_CP012090
• Organism: Mycobacterium tuberculosis W-148

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P67239
• Locus tag: TBPG_RS03155
• Protein ID: WP_003403187.1
• Coordinates: 701792..702193 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ91
• Locus tag: TBPG_RS03150
• Protein ID: WP_003403184.1
• Coordinates: 701550..701795 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBPG_RS03115	696830..697360	-	531	WP_003917320.1	two component system sensor kinase HK2	-
TBPG_RS03120	697344..698105	-	762	WP_003403148.1	two-component system response regulator TcrA	-
TBPG_RS03125	698162..698473	+	312	WP_003403164.1	hypothetical protein	-
TBPG_RS03130	698545..699495	+	951	WP_003900184.1	DUF1259 domain-containing protein	-
TBPG_RS03135	699736..700320	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
TBPG_RS03140	700322..701032	+	711	Protein_624	transposase	-
TBPG_RS03145	701035..701505	+	471	WP_003898523.1	hypothetical protein	-
TBPG_RS03150	701550..701795	+	246	WP_003403184.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TBPG_RS03155	701792..702193	+	402	WP_003403187.1	type II toxin-antitoxin system VapC family toxin	Toxin
TBPG_RS03165	702549..703319	+	771	Protein_628	IS3-like element IS987 family transposase	-
TBPG_RS03170	703427..703648	+	222	WP_003906064.1	hypothetical protein	-
TBPG_RS03175	703743..704888	-	1146	WP_003417299.1	FHA domain-containing protein	-
TBPG_RS03185	705533..706597	+	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-
TBPG_RS03190	706694..707068	+	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	699736..703319	3583

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14501.21 Da
• Isoelectric Point: 4.4463

>T55642 WP_003403187.1 NZ_CP012090:701792-702193 [Mycobacterium tuberculosis W-148]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Nucleotide

• Length: 402 bp

>T55642 NZ_CP012090:701792-702193 [Mycobacterium tuberculosis W-148]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8813.12 Da
• Isoelectric Point: 10.3486

>AT55642 WP_003403184.1 NZ_CP012090:701550-701795 [Mycobacterium tuberculosis W-148]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Nucleotide

• Length: 246 bp

>AT55642 NZ_CP012090:701550-701795 [Mycobacterium tuberculosis W-148]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BSD6

Antitoxin

• AlphaFold DB: G0TQ91