Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 3232643..3233421 Replicon chromosome
Accession NZ_CP012076
Organism Bordetella hinzii strain F582

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H4W6J9
Locus tag ACR54_RS15435 Protein ID WP_029577226.1
Coordinates 3232918..3233421 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H4W2N5
Locus tag ACR54_RS15430 Protein ID WP_029577227.1
Coordinates 3232643..3232921 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACR54_RS15400 3227795..3229009 + 1215 WP_029577233.1 phage portal protein -
ACR54_RS15405 3229006..3229443 + 438 WP_029577232.1 HNH endonuclease -
ACR54_RS15410 3229494..3229952 + 459 WP_029577231.1 hypothetical protein -
ACR54_RS15415 3229949..3231445 + 1497 WP_029577230.1 terminase -
ACR54_RS15420 3231584..3231919 + 336 WP_029577229.1 phage head closure protein -
ACR54_RS15425 3231916..3232194 + 279 WP_029577228.1 head-tail connector protein -
ACR54_RS15430 3232643..3232921 + 279 WP_029577227.1 DUF1778 domain-containing protein Antitoxin
ACR54_RS15435 3232918..3233421 + 504 WP_029577226.1 GNAT family N-acetyltransferase Toxin
ACR54_RS15440 3233437..3233868 - 432 WP_029577225.1 hypothetical protein -
ACR54_RS15445 3233865..3235220 - 1356 WP_029577224.1 recombinase family protein -
ACR54_RS23275 3235217..3235384 - 168 Protein_3061 DUF2924 domain-containing protein -
ACR54_RS15450 3235393..3236199 + 807 WP_029577223.1 hypothetical protein -
ACR54_RS15455 3236208..3237164 + 957 WP_029577222.1 hypothetical protein -
ACR54_RS15460 3237230..3237454 + 225 WP_029577221.1 DUF2188 domain-containing protein -
ACR54_RS15465 3237643..3237855 + 213 WP_029577220.1 helix-turn-helix domain-containing protein -
ACR54_RS15470 3237852..3238322 + 471 WP_029577219.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3213939..3263817 49878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-147)

Antitoxin

Vibrio phage ICP1, Orf50

(11-86)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18326.13 Da        Isoelectric Point: 7.2395

>T55608 WP_029577226.1 NZ_CP012076:3232918-3233421 [Bordetella hinzii]
MSNDYSPVRKLAATDQVDAFDCGQAALNQFLQRYALINQKANSAQTYVCCQGDVVVGFYSLAVGSVDPEAAPSRVMKGLA
RHPVPVMILARLAVDKAHQCKGLGQALLKDALLRTAQAADIAGIRCLLVHAKDDAARQWYESWEFEPSPTDPYHLFLMLK
DLKSMLS

Download         Length: 504 bp

>T55608 NZ_CP012076:3232918-3233421 [Bordetella hinzii]
TTGAGCAATGACTACTCGCCCGTTCGCAAGCTGGCTGCAACGGATCAGGTCGATGCGTTCGACTGCGGCCAGGCCGCGCT
GAACCAGTTCCTGCAGCGCTACGCGCTGATCAACCAAAAGGCCAATAGCGCGCAGACCTATGTCTGCTGCCAGGGTGATG
TGGTGGTCGGCTTCTACAGCCTCGCGGTCGGCAGTGTCGATCCGGAAGCCGCGCCGTCGCGAGTGATGAAGGGGCTGGCG
CGTCACCCGGTGCCGGTCATGATCCTGGCTCGGCTCGCCGTGGACAAGGCGCATCAGTGTAAAGGTCTGGGCCAGGCCTT
GCTCAAAGACGCCCTGCTGCGCACCGCACAGGCTGCCGACATCGCCGGGATTCGCTGCCTGTTGGTCCATGCCAAGGACG
ACGCGGCGCGGCAGTGGTACGAATCCTGGGAATTCGAGCCCAGCCCGACCGATCCGTACCATCTGTTCCTGATGCTCAAG
GATCTCAAAAGCATGTTGAGCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10344.85 Da        Isoelectric Point: 9.2519

>AT55608 WP_029577227.1 NZ_CP012076:3232643-3232921 [Bordetella hinzii]
MSTLNLSKTERIDVRASTPVKQLLQEAARACHKNVSEFLLDAGVTAAAQTLADRRQFVLDDTQWQAFQEALDRPVQSKPR
LKKLLREPGVLD

Download         Length: 279 bp

>AT55608 NZ_CP012076:3232643-3232921 [Bordetella hinzii]
ATGAGCACCCTGAATCTTTCCAAGACCGAACGCATTGACGTTCGTGCCAGCACGCCAGTCAAGCAACTGCTGCAGGAAGC
CGCACGCGCCTGCCACAAGAACGTGAGCGAGTTCCTGCTCGACGCGGGCGTGACGGCGGCCGCGCAGACGCTGGCGGATC
GTCGCCAGTTCGTGCTGGACGACACACAGTGGCAGGCCTTCCAGGAGGCGCTGGACCGCCCGGTGCAAAGCAAGCCGCGT
CTGAAGAAGTTGCTGCGTGAACCTGGGGTGCTGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H4W6J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H4W2N5

References