Detailed information of TA system TA055607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1910553..1911204
• Replicon: chromosome
• Accession: NZ_CP012076
• Organism: Bordetella hinzii strain F582

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ACR54_RS23200
• Protein ID: WP_080666588.1
• Coordinates: 1911028..1911204 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0H4WIS4
• Locus tag: ACR54_RS09310
• Protein ID: WP_029580464.1
• Coordinates: 1910553..1910969 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACR54_RS09285	1905898..1907883	+	1986	WP_029580459.1	hypothetical protein	-
ACR54_RS09290	1907911..1908510	+	600	WP_029580460.1	hypothetical protein	-
ACR54_RS09295	1908610..1909050	+	441	WP_029580461.1	hypothetical protein	-
ACR54_RS09300	1909056..1909547	+	492	WP_029580462.1	hypothetical protein	-
ACR54_RS23195	1909574..1910080	+	507	WP_080666598.1	DUF2514 family protein	-
ACR54_RS23440	1910056..1910553	-	498	WP_144417576.1	hypothetical protein	-
ACR54_RS09310	1910553..1910969	-	417	WP_029580464.1	antitoxin	Antitoxin
ACR54_RS23200	1911028..1911204	-	177	WP_080666588.1	type II toxin-antitoxin system HicA family toxin	Toxin
ACR54_RS09315	1911593..1912285	-	693	WP_029580465.1	SOS response-associated peptidase family protein	-
ACR54_RS09320	1912599..1913555	+	957	WP_144417577.1	hypothetical protein	-
ACR54_RS09325	1913742..1914230	-	489	WP_029580467.1	membrane protein	-
ACR54_RS09330	1914369..1916024	-	1656	WP_029580468.1	PAS domain-containing methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1864579..1912285	47706

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6522.48 Da
• Isoelectric Point: 11.0738

>T55607 WP_080666588.1 NZ_CP012076:c1911204-1911028 [Bordetella hinzii]
VKTSEFRRWLAEQGATFKEGSAHTKVYLNGKQTTLPRHGSQEIGEGLRRAILKQLGIK

Nucleotide

• Length: 177 bp

>T55607 NZ_CP012076:c1911204-1911028 [Bordetella hinzii]
GTGAAAACAAGCGAGTTCAGACGGTGGCTCGCTGAACAAGGGGCAACTTTCAAAGAGGGCTCAGCCCACACGAAGGTTTA
CCTGAACGGCAAGCAAACCACCCTGCCACGGCACGGAAGCCAGGAAATAGGCGAAGGACTGAGGCGGGCAATTCTGAAAC
AGCTAGGAATCAAGTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15149.53 Da
• Isoelectric Point: 4.6381

>AT55607 WP_029580464.1 NZ_CP012076:c1910969-1910553 [Bordetella hinzii]
MLRYPAKIAPDTVGFMVTFRDIPEALSAGQTREEAEAMAADALLVAMDFYFEDRRPVPPPSAPVGDEVMIALPASASAKV
LLLNEMLAQQVTPSELARRMETRKQEVNRIIDLNHATKIDTIAAALTSLGRELELTVR

Nucleotide

• Length: 417 bp

>AT55607 NZ_CP012076:c1910969-1910553 [Bordetella hinzii]
ATGCTGCGCTACCCCGCAAAGATCGCACCCGATACCGTCGGTTTCATGGTGACTTTCCGCGACATCCCTGAAGCGCTTTC
CGCCGGCCAGACCCGCGAGGAAGCCGAAGCCATGGCCGCTGACGCGCTTCTTGTCGCTATGGACTTCTACTTCGAAGACC
GGCGCCCGGTACCGCCCCCCTCGGCGCCCGTCGGCGACGAGGTAATGATCGCCCTGCCGGCGAGCGCGTCCGCCAAAGTG
CTGCTGCTGAACGAAATGCTCGCCCAGCAGGTCACGCCCAGCGAGTTGGCCAGACGGATGGAAACCCGCAAGCAAGAGGT
AAACAGGATCATTGACTTGAACCACGCCACCAAGATCGACACTATCGCCGCGGCGCTCACCAGCCTCGGCCGCGAACTTG
AACTGACGGTGCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H4WIS4