Detailed information of TA system TA055606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1699130..1699954
• Replicon: chromosome
• Accession: NZ_CP012072
• Organism: Schaalia meyeri strain W712

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: ADJ76_RS07400
• Protein ID: WP_050695459.1
• Coordinates: 1699436..1699954 (+)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: ADJ76_RS07395
• Protein ID: WP_050695458.1
• Coordinates: 1699130..1699429 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADJ76_RS07375	1694582..1694872	-	291	WP_050695856.1	hypothetical protein	-
ADJ76_RS07380	1695047..1696413	-	1367	Protein_1438	ABC transporter permease	-
ADJ76_RS07385	1696410..1697195	-	786	WP_050695456.1	ABC transporter ATP-binding protein	-
ADJ76_RS09040	1697849..1698262	+	414	WP_162200541.1	excalibur calcium-binding domain-containing protein	-
ADJ76_RS09220	1698707..1698859	+	153	WP_050695457.1	hypothetical protein	-
ADJ76_RS07395	1699130..1699429	+	300	WP_050695458.1	DUF1778 domain-containing protein	Antitoxin
ADJ76_RS07400	1699436..1699954	+	519	WP_050695459.1	GNAT family N-acetyltransferase	Toxin
ADJ76_RS07405	1700053..1700454	-	402	WP_050695460.1	hypothetical protein	-
ADJ76_RS07410	1700531..1701463	-	933	WP_050695857.1	alpha/beta fold hydrolase	-
ADJ76_RS07415	1701486..1702235	+	750	WP_050695461.1	NADPH-dependent oxidoreductase	-
ADJ76_RS07420	1702325..1702981	+	657	WP_050695462.1	hypothetical protein	-
ADJ76_RS09045	1703250..1704182	+	933	WP_082175926.1	Abi family protein	-
ADJ76_RS07425	1704252..1704722	-	471	WP_050695463.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (31-141)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-84)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19341.11 Da
• Isoelectric Point: 7.3493

>T55606 WP_050695459.1 NZ_CP012072:1699436-1699954 [Schaalia meyeri]
MHVSVLQEPRPLEHGDDRARFQSENDEIDDWFHRYAWQNQQARNARVFVTVQEPEMVGFYALAMGSVERGRLPAQLKPQR
PPDPCPCLLLARLAVDRRAQGRGIGAALLKDALLRAYVLSREVGFAALLVHCADQQARDFYPSQSSQFVPCPGADNHLML
PLGAIKRCVEHA

Nucleotide

• Length: 519 bp

>T55606 NZ_CP012072:1699436-1699954 [Schaalia meyeri]
ATGCACGTATCAGTCCTACAGGAGCCACGTCCCCTCGAACACGGGGATGACCGCGCGCGTTTCCAATCGGAGAACGACGA
GATTGACGACTGGTTCCACCGCTACGCTTGGCAGAACCAACAAGCGAGGAACGCGCGCGTATTCGTCACGGTACAGGAGC
CTGAGATGGTCGGGTTCTACGCTCTCGCCATGGGTTCTGTGGAGCGCGGCAGGCTCCCGGCTCAACTAAAGCCGCAGCGC
CCTCCAGATCCCTGCCCTTGCCTCTTGCTTGCCCGTCTGGCCGTCGACCGGCGAGCACAGGGGCGAGGCATCGGCGCGGC
GCTGCTGAAAGATGCCCTATTGCGGGCCTACGTCCTCAGCCGTGAAGTCGGATTTGCAGCACTGTTGGTCCACTGCGCGG
ACCAACAGGCGCGCGACTTCTACCCCAGCCAGTCGTCGCAATTCGTTCCCTGCCCGGGGGCGGACAACCATCTGATGCTG
CCGCTTGGCGCGATCAAACGCTGCGTCGAACACGCATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11333.89 Da
• Isoelectric Point: 10.3390

>AT55606 WP_050695458.1 NZ_CP012072:1699130-1699429 [Schaalia meyeri]
MSTAKTRRLDLRLTETQDTLIRRAAEQEARSVSDFVLSAAALEAQRRLTDQRVFVLNDKQYAHFEAILQAPLKDDPKLRK
LFERPSPFGTHIDTSPARP

Nucleotide

• Length: 300 bp

>AT55606 NZ_CP012072:1699130-1699429 [Schaalia meyeri]
ATGAGCACCGCGAAGACACGACGCTTGGACCTGCGCCTGACCGAAACGCAGGACACCCTCATTCGCCGCGCAGCAGAACA
GGAAGCTCGCAGCGTCAGCGATTTCGTCCTGTCCGCAGCTGCATTGGAAGCGCAGCGACGCCTGACCGACCAACGCGTAT
TTGTCTTGAACGACAAGCAGTACGCGCACTTTGAAGCAATCCTTCAGGCCCCGCTCAAGGACGATCCAAAACTGCGCAAG
CTCTTCGAGCGCCCCTCACCCTTTGGCACCCACATCGATACGAGCCCCGCGCGCCCCTGA