Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 257489..258051 Replicon chromosome
Accession NZ_CP012072
Organism Schaalia meyeri strain W712

Toxin (Protein)


Gene name vapC Uniprot ID A0A1H1P0K6
Locus tag ADJ76_RS01165 Protein ID WP_050694425.1
Coordinates 257680..258051 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H1P124
Locus tag ADJ76_RS01160 Protein ID WP_050695718.1
Coordinates 257489..257683 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADJ76_RS01140 253472..254434 + 963 WP_050694423.1 hypothetical protein -
ADJ76_RS01145 254509..255030 + 522 WP_050694424.1 hypothetical protein -
ADJ76_RS01150 255684..255950 - 267 Protein_224 hypothetical protein -
ADJ76_RS08900 255971..257245 + 1275 Protein_225 IS30 family transposase -
ADJ76_RS01160 257489..257683 + 195 WP_050695718.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ADJ76_RS01165 257680..258051 + 372 WP_050694425.1 type II toxin-antitoxin system VapC family toxin Toxin
ADJ76_RS01170 258175..260340 + 2166 WP_050694426.1 AAA family ATPase -
ADJ76_RS01175 260337..261377 + 1041 WP_050695719.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
ADJ76_RS01180 261822..262694 - 873 WP_050694427.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13991.26 Da        Isoelectric Point: 7.1683

>T55605 WP_050694425.1 NZ_CP012072:257680-258051 [Schaalia meyeri]
MRILVDTNVWIDHLRTTEPVLVDLLERDQVCVHQSVITELALGNLKDRSIFLKALERLMIVRNVDDQGVRYFIQERRLWG
RGLSAVDAAILASVVVTPGMSLWTRDKRLRQAARDAGVLADLD

Download         Length: 372 bp

>T55605 NZ_CP012072:257680-258051 [Schaalia meyeri]
ATGAGAATCCTCGTTGACACGAACGTGTGGATCGACCACCTGCGCACAACCGAGCCAGTCCTGGTCGATCTGCTCGAACG
TGATCAGGTGTGCGTGCACCAGAGCGTCATCACTGAGCTGGCATTGGGCAACCTGAAAGACCGGTCGATCTTCCTGAAGG
CGTTAGAACGCTTGATGATAGTGCGTAACGTGGATGATCAGGGGGTGCGCTATTTTATCCAGGAGCGGCGGCTGTGGGGT
AGGGGGCTGAGTGCTGTCGATGCGGCAATTCTGGCGAGCGTTGTTGTAACCCCTGGCATGTCACTGTGGACACGCGACAA
GCGCCTGCGTCAGGCCGCGCGCGACGCGGGTGTGCTCGCGGACCTCGACTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6886.81 Da        Isoelectric Point: 5.0339

>AT55605 WP_050695718.1 NZ_CP012072:257489-257683 [Schaalia meyeri]
MRTTVTLDDDLLARAEELTGIRERSVLIRDAVELLVRIESGRQLAALGGSDPGAEAAPRSRARA

Download         Length: 195 bp

>AT55605 NZ_CP012072:257489-257683 [Schaalia meyeri]
ATGAGAACGACTGTGACACTCGATGATGACCTGCTCGCCCGCGCTGAGGAGCTCACTGGGATCAGAGAGCGCTCCGTTTT
GATCAGAGACGCGGTTGAGCTCCTCGTCCGTATCGAGAGCGGCCGTCAGTTAGCTGCGCTCGGTGGTAGTGATCCGGGAG
CGGAGGCTGCGCCGCGGAGCCGGGCGCGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H1P0K6

Antitoxin

Source ID Structure
AlphaFold DB A0A1H1P124

References