Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1596648..1597202 Replicon chromosome
Accession NZ_CP012070
Organism Arsenicicoccus sp. oral taxon 190 strain F0371

Toxin (Protein)


Gene name mazF Uniprot ID A0A0K1F9V7
Locus tag ADJ73_RS07530 Protein ID WP_050347764.1
Coordinates 1596885..1597202 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0K1F957
Locus tag ADJ73_RS07525 Protein ID WP_050347763.1
Coordinates 1596648..1596881 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADJ73_RS07500 1592271..1593278 + 1008 WP_050347758.1 c-type cytochrome biogenesis protein CcsB -
ADJ73_RS07505 1593284..1593619 + 336 WP_050347759.1 DUF4229 domain-containing protein -
ADJ73_RS07510 1593616..1594251 + 636 WP_050347760.1 LysE family translocator -
ADJ73_RS07515 1594276..1595154 - 879 WP_050347761.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
ADJ73_RS07520 1595362..1596582 + 1221 WP_050347762.1 prohibitin family protein -
ADJ73_RS07525 1596648..1596881 + 234 WP_050347763.1 hypothetical protein Antitoxin
ADJ73_RS07530 1596885..1597202 + 318 WP_050347764.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ADJ73_RS07535 1597206..1598363 - 1158 WP_082176822.1 o-succinylbenzoate--CoA ligase -
ADJ73_RS07540 1598432..1598701 + 270 WP_156188164.1 antitoxin -
ADJ73_RS07545 1598698..1599114 + 417 WP_050347767.1 type II toxin-antitoxin system VapC family toxin -
ADJ73_RS07550 1599244..1599618 + 375 WP_156188165.1 hypothetical protein -
ADJ73_RS07555 1600044..1600340 + 297 WP_050347769.1 putative addiction module antidote protein -
ADJ73_RS07560 1600449..1601207 + 759 WP_050349307.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-94)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11045.77 Da        Isoelectric Point: 5.8099

>T55602 WP_050347764.1 NZ_CP012070:1596885-1597202 [Arsenicicoccus sp. oral taxon 190]
VREICLARLDKTRPVLVLTREGARAAMTKVTVAPITSTVKGLSSEVPLGPRNGLDHGCAAALDNTVTVPTSTLGRTIGYL
YGDQERALAEAVVLAFDLDLALLGE

Download         Length: 318 bp

>T55602 NZ_CP012070:1596885-1597202 [Arsenicicoccus sp. oral taxon 190]
GTGCGCGAGATCTGCCTGGCGCGCCTGGACAAGACCAGGCCCGTACTCGTCCTGACTCGAGAGGGGGCGCGCGCCGCCAT
GACCAAGGTCACCGTCGCCCCCATCACCTCCACGGTCAAAGGGCTCTCCAGCGAGGTCCCTCTCGGCCCCCGCAACGGGT
TGGACCACGGCTGTGCTGCAGCGTTGGACAACACAGTCACCGTCCCGACCTCGACGCTCGGCCGGACGATCGGTTACCTC
TACGGAGACCAGGAGAGGGCGCTCGCCGAGGCTGTCGTCCTGGCCTTCGACCTGGACCTGGCGCTCCTCGGCGAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8171.30 Da        Isoelectric Point: 4.6507

>AT55602 WP_050347763.1 NZ_CP012070:1596648-1596881 [Arsenicicoccus sp. oral taxon 190]
MTTQIAVRLPDEVVGFLDRSVAAGLVSSRAALVTQAVEREMRRQAALADVDVLRKQGPADDLDGLVAWTVGHASLEG

Download         Length: 234 bp

>AT55602 NZ_CP012070:1596648-1596881 [Arsenicicoccus sp. oral taxon 190]
ATGACGACGCAGATCGCTGTCCGGCTCCCCGACGAGGTCGTGGGTTTCCTTGACCGCAGCGTGGCGGCGGGGCTTGTCTC
CAGTCGTGCCGCGCTCGTCACACAAGCCGTGGAGCGGGAGATGCGTCGTCAAGCGGCGCTGGCCGACGTGGACGTCCTGC
GTAAGCAGGGGCCTGCCGACGACCTGGATGGCCTCGTGGCGTGGACGGTGGGTCACGCCAGCCTCGAGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K1F9V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1F957

References