Detailed information of TA system TA055601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 1249354..1250006
• Replicon: chromosome
• Accession: NZ_CP012070
• Organism: Arsenicicoccus sp. oral taxon 190 strain F0371

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ADJ73_RS05880
• Protein ID: WP_050347489.1
• Coordinates: 1249614..1250006 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0K1F951
• Locus tag: ADJ73_RS05875
• Protein ID: WP_050347488.1
• Coordinates: 1249354..1249617 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADJ73_RS05855	1244589..1245080	-	492	WP_050347486.1	GNAT family N-acetyltransferase	-
ADJ73_RS05860	1245324..1247132	-	1809	WP_050349274.1	hypothetical protein	-
ADJ73_RS05865	1247282..1248127	-	846	WP_082176770.1	SRPBCC family protein	-
ADJ73_RS05870	1248236..1249060	-	825	WP_050347487.1	SDR family NAD(P)-dependent oxidoreductase	-
ADJ73_RS05875	1249354..1249617	+	264	WP_050347488.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ADJ73_RS05880	1249614..1250006	+	393	WP_050347489.1	type II toxin-antitoxin system VapC family toxin	Toxin
ADJ73_RS16550	1250094..1250234	+	141	Protein_1161	MerR family DNA-binding transcriptional regulator	-
ADJ73_RS05885	1250346..1250543	-	198	WP_050347490.1	hypothetical protein	-
ADJ73_RS05890	1250568..1251257	-	690	WP_050347491.1	CPBP family intramembrane metalloprotease	-
ADJ73_RS05895	1251333..1251890	-	558	WP_050347492.1	dihydrofolate reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-60)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14051.88 Da
• Isoelectric Point: 4.7614

>T55601 WP_050347489.1 NZ_CP012070:1249614-1250006 [Arsenicicoccus sp. oral taxon 190]
MIRYLDTSAALKLLVDESESAALADALTRGARDGDRLVASMLLHTELHCALGRRRELDPVSVRDTLDAVTLVDVTRDDLM
RAASSGWGLRSADAIHLATALRLDVDEMLTYDDELAAAAQRAGLRANGPH

Nucleotide

• Length: 393 bp

>T55601 NZ_CP012070:1249614-1250006 [Arsenicicoccus sp. oral taxon 190]
ATGATCCGATATCTCGACACCTCTGCCGCGCTCAAGCTGCTCGTCGACGAGTCCGAGTCCGCCGCGCTGGCTGACGCCCT
GACGCGGGGAGCACGGGACGGCGACCGTCTGGTCGCCTCGATGCTGCTCCACACCGAGCTGCACTGCGCCCTCGGGCGTC
GGCGGGAGCTCGACCCGGTGTCGGTCCGGGACACGCTGGACGCGGTCACCCTGGTCGACGTCACGCGAGACGACCTGATG
CGCGCGGCATCATCCGGATGGGGCCTGCGCAGCGCGGACGCCATCCATCTCGCGACCGCGCTGCGCCTCGACGTCGACGA
GATGCTCACGTATGACGACGAGCTCGCCGCCGCAGCCCAGCGTGCGGGACTGCGCGCCAACGGTCCCCACTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9428.73 Da
• Isoelectric Point: 11.9771

>AT55601 WP_050347488.1 NZ_CP012070:1249354-1249617 [Arsenicicoccus sp. oral taxon 190]
METIPHRELRNNSSAILARVAAGESMAVTNHGTVAAILSPPTASTLARLELAGQLRPARRPRTDFTRIRRVASEPSSDIL
ADLRGDR

Nucleotide

• Length: 264 bp

>AT55601 NZ_CP012070:1249354-1249617 [Arsenicicoccus sp. oral taxon 190]
ATGGAGACCATCCCGCACAGGGAGCTGCGCAACAACAGCAGTGCGATCCTGGCGCGGGTCGCGGCCGGCGAGTCGATGGC
GGTGACCAACCACGGCACCGTGGCAGCCATCCTGTCCCCGCCGACCGCGTCCACGCTCGCGCGACTGGAGCTGGCTGGGC
AGCTGCGCCCCGCGAGGCGACCACGCACCGACTTCACCCGCATCCGGCGAGTGGCCTCGGAGCCGTCCTCGGACATCCTC
GCCGACCTCCGCGGCGACCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A0K1F951