Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 87153..87802 Replicon chromosome
Accession NZ_CP012070
Organism Arsenicicoccus sp. oral taxon 190 strain F0371

Toxin (Protein)


Gene name vapC Uniprot ID A0A0K1F696
Locus tag ADJ73_RS00400 Protein ID WP_050346612.1
Coordinates 87153..87548 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0K1F6W6
Locus tag ADJ73_RS00405 Protein ID WP_050346613.1
Coordinates 87545..87802 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADJ73_RS00375 82860..83288 + 429 WP_050346607.1 DUF4307 domain-containing protein -
ADJ73_RS00380 83424..83933 + 510 WP_082176637.1 transcription elongation factor GreA -
ADJ73_RS00385 84010..85359 - 1350 WP_050346609.1 glutamate mutase L -
ADJ73_RS00390 85424..86389 + 966 WP_050346610.1 acyl-CoA thioesterase -
ADJ73_RS00395 86435..87124 + 690 WP_082177081.1 peptide-methionine (S)-S-oxide reductase MsrA -
ADJ73_RS00400 87153..87548 - 396 WP_050346612.1 PIN domain-containing protein Toxin
ADJ73_RS00405 87545..87802 - 258 WP_050346613.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ADJ73_RS00410 87842..88402 - 561 WP_050346614.1 maleylpyruvate isomerase family mycothiol-dependent enzyme -
ADJ73_RS00415 88457..89305 + 849 WP_050346615.1 helix-turn-helix transcriptional regulator -
ADJ73_RS00420 89394..90176 - 783 WP_050346616.1 enoyl-CoA hydratase/isomerase family protein -
ADJ73_RS00425 90321..90845 - 525 WP_050346617.1 hypothetical protein -
ADJ73_RS00430 91153..92142 + 990 WP_082177082.1 SGNH/GDSL hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13906.90 Da        Isoelectric Point: 4.6787

>T55600 WP_050346612.1 NZ_CP012070:c87548-87153 [Arsenicicoccus sp. oral taxon 190]
VTAGRLDTSVWIAGEIGRPISVEALPERSYVSVITVAEIEAGVLAAGDVATRAARMATATALAMVESLPVDGPVAREWAT
MRVLLRDAGRRVNVNDLWIAATARAHDLTVYTQDGDFDVLAEIGGIRVVHV

Download         Length: 396 bp

>T55600 NZ_CP012070:c87548-87153 [Arsenicicoccus sp. oral taxon 190]
GTGACGGCGGGCCGGCTGGACACGAGCGTCTGGATCGCGGGCGAGATCGGTCGCCCCATCTCCGTGGAGGCACTCCCCGA
GCGGTCGTACGTCTCGGTGATCACCGTTGCCGAGATCGAGGCCGGCGTCCTCGCAGCCGGCGACGTCGCGACCCGCGCCG
CACGCATGGCGACCGCCACCGCGCTCGCCATGGTCGAGTCGCTGCCGGTCGACGGACCGGTAGCACGTGAGTGGGCGACG
ATGCGGGTCCTGCTCCGCGACGCCGGTCGGCGCGTCAACGTCAACGACCTCTGGATCGCCGCCACCGCCCGTGCCCATGA
CCTGACGGTCTACACCCAGGACGGAGACTTCGACGTGCTGGCCGAGATCGGTGGGATCCGCGTGGTCCACGTGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9266.44 Da        Isoelectric Point: 10.7180

>AT55600 WP_050346613.1 NZ_CP012070:c87802-87545 [Arsenicicoccus sp. oral taxon 190]
MTIIAARELRNHTGALLARVAAGERLTITHRGEPVAELTRAGHRRRRYLERDEVLAVLHSGRGGSWTQDQAWIGGGTTDD
LGPIG

Download         Length: 258 bp

>AT55600 NZ_CP012070:c87802-87545 [Arsenicicoccus sp. oral taxon 190]
ATGACGATCATCGCGGCCCGAGAGCTGAGGAACCACACCGGAGCCCTCCTCGCCCGTGTCGCTGCGGGTGAGCGACTCAC
CATCACCCACCGCGGCGAGCCCGTGGCGGAGCTGACCCGTGCGGGACATCGACGCCGCCGCTACCTGGAGCGGGACGAGG
TGCTCGCCGTCTTGCACTCGGGTCGGGGCGGATCCTGGACCCAGGACCAGGCCTGGATCGGCGGAGGCACCACCGACGAC
CTCGGGCCCATCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K1F696

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1F6W6

References