Detailed information of TA system TA055599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafQ-mazE/YafQ-DinJ
• Location: 3194496..3194955
• Replicon: chromosome
• Accession: NZ_CP012069
• Organism: Olsenella sp. oral taxon 807 strain F0089

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: ADJ70_RS13770
• Protein ID: WP_083444058.1
• Coordinates: 3194496..3194708 (-)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A0K1F2H5
• Locus tag: ADJ70_RS13775
• Protein ID: WP_050342344.1
• Coordinates: 3194701..3194955 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ADJ70_RS14835	3190759..3191508	+	750	WP_157051566.1	hypothetical protein	-
ADJ70_RS13765	3192026..3194467	+	2442	WP_050344633.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
ADJ70_RS13770	3194496..3194708	-	213	WP_083444058.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
ADJ70_RS13775	3194701..3194955	-	255	WP_050342344.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ADJ70_RS13780	3195539..3196099	+	561	WP_050342346.1	hypothetical protein	-
ADJ70_RS13785	3196300..3197772	-	1473	WP_050342348.1	putative DNA binding domain-containing protein	-
ADJ70_RS14840	3198123..3198266	+	144	WP_157051567.1	hypothetical protein	-
ADJ70_RS13790	3198879..3199520	-	642	WP_050342350.1	Fic family protein	-
ADJ70_RS13795	3199517..3199744	-	228	WP_050342352.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-69)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-82)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8597.09 Da
• Isoelectric Point: 11.1748

>T55599 WP_083444058.1 NZ_CP012069:c3194708-3194496 [Olsenella sp. oral taxon 807]
MLKSIRVLPQFERDVKRLKKKHFPLDKLRSAVSAIFKDSRDELRRLRDHELKGNWLGYRELHIERNWLLT

Nucleotide

• Length: 213 bp

>T55599 NZ_CP012069:c3194708-3194496 [Olsenella sp. oral taxon 807]
ATGCTTAAGAGCATCAGGGTTCTTCCGCAGTTCGAACGTGACGTGAAGCGCCTCAAGAAGAAGCACTTTCCCTTAGACAA
GCTGAGGTCTGCCGTTAGCGCCATCTTCAAAGATAGCAGAGACGAGCTGCGGAGACTACGCGATCACGAGCTCAAGGGAA
ACTGGTTAGGCTACAGAGAGCTTCACATAGAGCGGAACTGGCTGCTAACGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9540.70 Da
• Isoelectric Point: 4.4843

>AT55599 WP_050342344.1 NZ_CP012069:c3194955-3194701 [Olsenella sp. oral taxon 807]
MSEARLSIRTDSALKEQARRLYESMGLDLTTAVNMFLRQSVVDHGMPFKPTAESPEDINARREDRMGEGHTFATVDDMMD
YLDA

Nucleotide

• Length: 255 bp

>AT55599 NZ_CP012069:c3194955-3194701 [Olsenella sp. oral taxon 807]
ATGTCAGAGGCACGCCTGAGCATCCGCACTGACAGTGCGCTCAAGGAGCAGGCACGCAGACTGTATGAGAGCATGGGGCT
CGACCTCACTACTGCTGTCAACATGTTTCTGCGTCAGTCTGTCGTGGACCATGGCATGCCCTTTAAACCGACCGCAGAAA
GCCCAGAGGACATTAATGCCAGGCGCGAGGATCGTATGGGAGAGGGGCACACATTCGCCACGGTTGACGACATGATGGAC
TACCTCGATGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0K1F2H5