Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2171913..2173471 Replicon chromosome
Accession NZ_CP012067
Organism Aggregatibacter aphrophilus strain W10433

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ADJ80_RS10030 Protein ID WP_080988267.1
Coordinates 2172191..2173471 (+) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ADJ80_RS10025 Protein ID WP_050693978.1
Coordinates 2171913..2172191 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADJ80_RS10005 2167087..2167569 - 483 WP_005700985.1 DNA starvation/stationary phase protection protein -
ADJ80_RS10010 2167760..2168920 + 1161 WP_050693976.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
ADJ80_RS10015 2168933..2170447 + 1515 WP_167552694.1 DHA2 family efflux MFS transporter permease subunit -
ADJ80_RS10020 2170704..2171759 + 1056 WP_050693977.1 ABC transporter substrate-binding protein -
ADJ80_RS10025 2171913..2172191 + 279 WP_050693978.1 helix-turn-helix domain-containing protein Antitoxin
ADJ80_RS10030 2172191..2173471 + 1281 WP_080988267.1 type II toxin-antitoxin system HipA family toxin Toxin
ADJ80_RS10035 2173504..2174580 - 1077 WP_005703915.1 HpaII family restriction endonuclease -
ADJ80_RS10040 2174573..2175655 - 1083 WP_050693980.1 DNA cytosine methyltransferase -
ADJ80_RS10045 2175636..2176061 - 426 WP_032995178.1 DNA mismatch endonuclease Vsr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 48983.27 Da        Isoelectric Point: 8.0608

>T55597 WP_080988267.1 NZ_CP012067:2172191-2173471 [Aggregatibacter aphrophilus]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDPVYNFFDNLLPDNEQIRSRIQQS
FQTSTKSPFDLLSAIGQDCIGAIQLYHGQSRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKAFGLPVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMAWHGENKHYLWDKIQLRHIFNTAKLAGLAKETVEDILHEISALYPRISG
INTHGLPDEIVDPIFMGLEMQMKKIS

Download         Length: 1281 bp

>T55597 NZ_CP012067:2172191-2173471 [Aggregatibacter aphrophilus]
ATGAGTAACTCGATTCTAAACGTTGCCATGAATGGCTTGTTAGTCGGTGAATGGCGAAAACTCACCAGTGGCGCAACCGA
ATTTCAGTATGCGGAAAAATGGCTTGAATCTGTTCGCTCGCGCCCTATTTCATTGTCACTGCCCTTGTCGCACAAAATTT
ATCGAGGAGATCCCGTTTACAATTTCTTCGATAATCTCCTCCCGGACAATGAGCAGATCCGTTCACGCATTCAACAAAGT
TTCCAAACATCAACGAAATCCCCATTTGATTTGCTTTCCGCGATTGGACAGGATTGTATTGGCGCAATTCAGCTTTATCA
TGGGCAGAGCCGCTCGGTACGTCAAATTTATGCAGAACCACTAAATGACAAAGAGGTGGAAAACGTGCTGAAAAACTACC
GCACTTTTCCTCTCGGCATGGAAGAAAGCGAGGATTTCCGAATTTCTTTAGCCGGCGCTCAGGAAAAAACAGCGCTGCTT
TATTACCAGAATCAATGGCAACGCCCTTTGCATTCCACTGCGACCAGCCATATTTTTAAACTCCCGATTGGTATGGTGGC
ACAAGGGCAGCTTGATCTTTCCGGCAGCTGTGAAAATGAATGGCTTTGCTTAAATATTATGAAAGCCTTCGGTTTGCCGG
TTCCTCGAAGTCAAATTCAGTATTTTGGTGAAATGAAAGTGCTGATTGTGGAGCGCTTTGATCGCCGTTGGTCTGAAAAT
AGGAGTTGGCTAATTCGTTTGCCACAGGAAGATATGTGCCAAGCACTCAACATCGCTCCTGCACGAAAATATGAAAATGA
CGGTGGTCCGAGCATTCTTCAAATTATGTCGCTTCTCAACGGTTCATCCAACGCCCAAGCAGATCGCAAGCAGTTTTTTA
AAGCGCAAATTATTTTTTGGCTGCTTTGTGCCATTGACGGCCATGGCAAAAATTTCAGTTTGTTTTTAGAACAAGAGAAC
CGCTATCGTCTAACGCCTTTTTATGACGTGATGTCCGCCTATCCGCTCATCAAACACAACGGACTACAAAAGCAAAAAGT
CAAAATGGCAATGGCGTGGCACGGCGAAAATAAACATTATTTATGGGATAAAATACAACTCCGCCACATTTTTAATACGG
CTAAACTCGCCGGCCTAGCAAAGGAAACAGTAGAAGACATTTTGCATGAAATCAGTGCACTATATCCAAGAATCAGTGGA
ATAAATACCCATGGATTGCCTGATGAAATTGTCGATCCTATTTTCATGGGATTGGAAATGCAGATGAAAAAGATAAGTTA
A

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10468.84 Da        Isoelectric Point: 5.1473

>AT55597 WP_050693978.1 NZ_CP012067:2171913-2172191 [Aggregatibacter aphrophilus]
MVITTAKMLSHVIREFRYQDNLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILSGLELELIVQPRKKSSDTAHSIK
EPTATYDDDEAW

Download         Length: 279 bp

>AT55597 NZ_CP012067:2171913-2172191 [Aggregatibacter aphrophilus]
ATGGTTATCACCACCGCAAAAATGCTTTCTCATGTGATTAGGGAGTTTCGCTATCAGGATAACCTGTCACAAACTGATGT
TGCTAAACTCGCCGGAACGACCCAAGCCAGAATTTCAGCGTTTGAGAATGAGCCGGAGCGTACTAAATTAGAAACACTAT
TTAAAATTCTGTCAGGATTAGAACTAGAGCTTATTGTACAACCACGCAAAAAGTCATCTGATACTGCCCATTCAATCAAA
GAGCCAACAGCAACATACGATGACGACGAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References